Rabbit SNX6 Polyclonal Antibody | anti-SNX6 antibody

SNX6 Rabbit Polyclonal

Cat. Num. AAA7604328

• Gene Names: SNX6; TFAF2; MSTP010
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SNX6; Polyclonal Antibody; SNX6 Rabbit Polyclonal; anti-SNX6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 418

• Applicable Applications for anti-SNX6 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Sorting nexin 6
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart slide using MBS7604328 (SNX6 Antibody) at dilution of 1:50)

Western Blot (WB)

(RAW 264.7 cells were subjected to SDS PAGE followed by western blot with MBS7604328 (SNX6 Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 88703041
• NCBI GeneID: 58533
• NCBI Accession #: NP_689419.2
• NCBI GenBank Nucleotide #: NM_152233.2
• Molecular Weight: 33,570 Da
• NCBI Official Full Name: sorting nexin-6 isoform b
• NCBI Official Synonym Full Names: sorting nexin 6
• NCBI Official Symbol: SNX6
• NCBI Official Synonym Symbols: TFAF2; MSTP010
• NCBI Protein Information: sorting nexin-6
• UniProt Protein Name: Sorting nexin-6
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX6
• UniProt Entry Name: SNX6_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

SNX6: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation. Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 14q13.1

Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; early endosome membrane; extrinsic to membrane; intracellular; nucleus; retromer complex

Molecular Function: phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: endocytosis; intracellular protein transport; negative regulation of epidermal growth factor receptor activity; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of macroautophagy; retrograde transport, endosome to Golgi; vesicle organization and biogenesis