Western Blot (WB)
(DcR3 mAb tested by Western blot. Detection of DcR3 by Western blot. The analysis was performed using 30 ug Jurkat whole-cell extract and DcR3 mAb at a 2 ug/ml dilution.)
Rabbit anti-Human DcR3 Monoclonal Antibody | anti-DcR3 antibody
DcR3 antibody (mAb)(Clone 37A565)
WB: 1-2ug/ml dilution
For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background.
Western Blot (WB)
(DcR3 mAb tested by Western blot. Detection of DcR3 by Western blot. The analysis was performed using 30 ug Jurkat whole-cell extract and DcR3 mAb at a 2 ug/ml dilution.)
Western Blot (WB)
(DcR3 mAb tested by Western blot. Detection of DcR3 by Western blot. The analysis was performed using 30 ug Jurkat whole-cell extract and DcR3 mAb at a 2 ug/ml dilution.)
Background: DcR3 (TNFRSF6B or tumor necrosis factor receptor superfamily member 6b) is thought to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. DcR3 acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Uniprot Description
TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q13.3
Cellular Component: extracellular space
Molecular Function: protein binding; receptor activity
Biological Process: apoptosis; negative regulation of apoptosis
Research Articles on DcR3
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Product Notes
The DcR3 tnfrsf6b (Catalog #AAA388689) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DcR3 antibody (mAb)(Clone 37A565) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DcR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications Validated: WB: 1-2ug/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all blocking solutions may also reduce background. Researchers should empirically determine the suitability of the DcR3 tnfrsf6b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DcR3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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