Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human skin tissue using Cytokeratin 1/5/10/14 (human), mAb (34betaE12), .)
Mouse anti-Human Cytokeratin 1/5/10/14 Monoclonal Antibody | anti-KRT1 antibody
Cytokeratin 1/5/10/14 (human) monoclonal antibody (34 beta E12) (Ready-to-Use)
Suggested dilutions/conditions may not be available for all applications.
Avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human skin tissue using Cytokeratin 1/5/10/14 (human), mAb (34betaE12), .)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of human skin tissue using Cytokeratin 1/5/10/14 (human), mAb (34betaE12), .)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Uniprot Description
K1: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K10.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytoskeleton; extracellular matrix; extracellular space; keratin filament; membrane; nucleus; plasma membrane
Molecular Function: carbohydrate binding; protein binding; receptor activity; structural molecule activity
Biological Process: complement activation, lectin pathway; fibrinolysis; negative regulation of inflammatory response; regulation of angiogenesis; response to oxidative stress; retinal homeostasis
Disease: Epidermolytic Hyperkeratosis; Ichthyosis Hystrix, Curth-macklin Type; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis; Keratosis Palmoplantaris Striata Iii; Palmoplantar Keratoderma, Epidermolytic; Palmoplantar Keratoderma, Nonepidermolytic
Research Articles on KRT1
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Product Notes
The KRT1 krt1 (Catalog #AAA565055) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Cytokeratin 1/5/10/14 (human) monoclonal antibody (34 beta E12) (Ready-to-Use) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cytokeratin 1/5/10/14 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) (PS), Western Blot (WB). Immunohistochemistry (paraffin sections; for optimal results, fixation in alcohol-based fixatives, such as methacarn, is recommended. Pretreatment with proteolytic enzymes such as trypsin may be required when formalin-fixed sections are to be stained. For optimal staining of prostate tissue higher concentrations of protease and longer incubation times are recommended, e.g., 0.5% trypsin at 37 degree C for 2 to 4 hours. Choose a good quality enzyme-linked anti-mouse IgG1 antibody for detection) Suggested dilutions/conditions may not be available for all applications. Researchers should empirically determine the suitability of the KRT1 krt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cytokeratin 1/5/10/14, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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