Western Blot (WB)
(Western blot of rat PC12 cells stimulated with calyculin A (100nM) for 30 min (lanes 1-4). Then the blot was treated with lambda phosphatase to dephosphorylate CRMP2 (lanes 2 & 4). The blot was probed with rabbit polyclonal anti-CRMP2 (C-terminal Region) antibody (lanes 1 & 2) or mouse monoclonal anti-CRMP2 (Thr-555) antibody (lanes 3 & 4).)
Mouse CRMP2 Monoclonal Antibody | anti-CRMP2 antibody
CRMP2 (Thr-555), phospho-specific M539 Antibody
WB: 1:500
Western Blot (WB)
(Western blot of rat PC12 cells stimulated with calyculin A (100nM) for 30 min (lanes 1-4). Then the blot was treated with lambda phosphatase to dephosphorylate CRMP2 (lanes 2 & 4). The blot was probed with rabbit polyclonal anti-CRMP2 (C-terminal Region) antibody (lanes 1 & 2) or mouse monoclonal anti-CRMP2 (Thr-555) antibody (lanes 3 & 4).)
Western Blot (WB)
(Western blot of rat PC12 cells stimulated with calyculin A (100nM) for 30 min (lanes 1-4). Then the blot was treated with lambda phosphatase to dephosphorylate CRMP2 (lanes 2 & 4). The blot was probed with rabbit polyclonal anti-CRMP2 (C-terminal Region) antibody (lanes 1 & 2) or mouse monoclonal anti-CRMP2 (Thr-555) antibody (lanes 3 & 4).)
Mimura, F. et al. (2006) J. Biol. Chem. 281(23):15970.
Arimura, N. et al. (2005) Mol. Cell. Biol. 25(22):9973.
Uchida, Y. et al. (2005) Genes to Cells 10:165.
Arimura, N. et al. (2000) J. Biol. Chem. 275(31):23973.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)).
Protein type: Motility/polarity/chemotaxis; Microtubule-binding
Chromosomal Location of Human Ortholog: 8p22-p21
Cellular Component: microtubule; growth cone; cell soma; membrane; mitochondrion; dendrite; terminal button; cytosol
Molecular Function: protein binding; dihydropyrimidinase activity; protein kinase binding
Biological Process: response to drug; nervous system development; axon guidance; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; endocytosis; cytoskeleton organization and biogenesis; response to cocaine; signal transduction; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Research Articles on CRMP2
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Product Notes
The CRMP2 dpysl2 (Catalog #AAA474270) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CRMP2 (Thr-555), phospho-specific M539 Antibody reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CRMP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). ELISA: 1:1000 WB: 1:500. Researchers should empirically determine the suitability of the CRMP2 dpysl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRMP2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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