Mouse COX4I1 Monoclonal Antibody | anti-COX4I1 antibody

COX4I1 Antibody

Cat. Num. AAA9602501

• Gene Names: COX4I1; COX4; COXIV; COX4-1; COXIV-1; COX IV-1
• Reactivity: Human, Mouse, Rat, Monkey
• Applications: Western Blot, Immunofluorescence, Immunocytochemistry, ELISA, Flow Cytometry, Functional Assay
• Purity: Affinity-Chromatography
• Synonyms: COX4I1; Monoclonal Antibody; COX4I1 Antibody; AL024441; COX 4; COX IV 1; COX IV; COX IV-1; Cox4; COX41_HUMAN; Cox4a; COX4B; COX4I2; COX4L2; COXIV; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial; Cytochrome c oxidase subunit 4 isoform 1; mitochondrial; Cytochrome C Oxidase subunit IV; Cytochrome c oxidase subunit IV isoform 1; Cytochrome c oxidase subunit IV isoform 2 (lung); Cytochrome c oxydase subunit 4; dJ857M17.2; MGC105470; MGC72016; anti-COX4I1 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat, Monkey
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: COX4I1 antibody detects endogenous levels of total COX4I1
• Purity/Purification: Affinity-Chromatography
• Form/Format: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 169

• Applicable Applications for anti-COX4I1 antibody: Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA), Flow Cytometry (FC/FACS)
• Application Notes: ELISA: 1:10000; WB: 1:500-1:2000; ICC: 1:200-1:1000; FC/FACS: 1:200-1:400
• Immunogen: Purified recombinant fragment of human COX4I1 expressed in E. Coli
• Subcellular Location: Mitochondrion Inner Membrane.
• Tissue Specificity: Ubiquitous.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Figure 1: Western blot analysis using COX4I1 mouse mAb against HEK293 (1), A549 (2) and PC12 (3) cell lysate.)

Related Product Information for anti-COX4I1 antibody

Description: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial-and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subunit Structure: Interacts with AFG1L (PubMed:26759378).
Similarity: Belongs to the cytochrome c oxidase IV family.

NCBI and Uniprot Product Information

• NCBI GI #: 974005293
• NCBI GeneID: 1327
• NCBI Accession #: NP_001305715.1
• NCBI GenBank Nucleotide #: NM_001318786.1
• UniProt Accession #: P13073; Q6P666; B2R4J2; D3DUM7
• Molecular Weight: Observed: 19 kDa; Predicted: 20 kDa
• NCBI Official Full Name: cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1
• NCBI Official Synonym Full Names: cytochrome c oxidase subunit 4I1
• NCBI Official Symbol: COX4I1
• NCBI Official Synonym Symbols: COX4; COXIV; COX4-1; COXIV-1; COX IV-1
• NCBI Protein Information: cytochrome c oxidase subunit 4 isoform 1, mitochondrial
• UniProt Protein Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
• Protein Family: Cytochrome c oxidase
• UniProt Gene Name: COX4I1
• UniProt Synonym Gene Names: COX4; COX IV-1

NCBI Description

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Uniprot Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.