Mouse COX 1 Monoclonal Antibody | anti-cko1 antibody
COX 1 (Cyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1, Ovarian Cancer Marker)
Gene Names
cko1; cko; ckx1
Reactivity
Bovine, Guinea Pig, Human, Rabbit, Sheep
Applications
ELISA, Immunohistochemistry
Purity
SupernatantSupernatant
Synonyms
COX 1; Monoclonal Antibody; COX 1 (Cyclooxygenase-1; PGHS-1; Prostaglandin Endoperoxide Synthase-1; PHS 1; Ovarian Cancer Marker); Anti -COX 1 (Cyclooxygenase-1; anti-cko1 antibody
Host
Mouse
Reactivity
Bovine, Guinea Pig, Human, Rabbit, Sheep
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
4i177
Specificity
Recognizes COX 1. Species crossreactivity: sheep, bovine, guinea pig, rabbit and human. Does not react with rat, mouse or canine.
Purity/Purification
Supernatant
Supernatant
Supernatant
Form/Format
Supplied as a liquid, 0.1% sodium azide.
Applicable Applications for anti-cko1 antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes
Suitable for use in ELISA and Immunohistochemistry. Not suitable for use in Western Blot.
Immunogen
cyo-5 hybridoma cell line of COX-1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-cko1 antibody
The prostanoid family includes PGD2, PGE2, PGF2alpha, PGI2, thromboxane A2 and prostaglandins. The prostaglandins (PGs) are implicated in various physiological and pathophysiological events, including male fertility, menstruation, ovulation, pregnancy, implantation and inflamatory and neoplastic diseases. The biosynthesis of PGs and some other prostanoids, is catalyzed in a rate limiting step by PG-H synthase (also known as cyclooxygenase (COX), PG-endoperoxidase synthase (PTGS)) which converts arachiodonic acid to prostaglandin/prostanoid precursor PGH2. Two cyclooxygenase isozymes, COX1 (human, 576aa, 69-72kD; chromosome 9) and COX2 (human, 604aa, 74kD; chromosome 1) have been identified. COX1, a constitutively expressed isoform, produces physiologically relevant prostanoids such as those in stomach and platelets. COX2 isoform is inducible and rapidly upregulated at inflamation sites and forms proinflamatory prostanoids. The overexpression of COX-2 also leads to tumerogenesis. Recently, a third isoform COX3 (canine 633aa; ~65kD in human aorta) has been reported. Two smaller COX1-derived proteins (partial COX1) PCOX1a (canine 414aa, ~53kDa in human aorta) and PCOX1b have also been characterized. The COX3, but not PCOX1a, possesses glycosylation dependent cyclooxygenase activity. The nonsteroidal antiinflammatory drugs (NSAIDs) reduce the formation of prostaglandins by inhibiting the activity of cyclooxygenases (COX1, COX2 and COX3), This ability was associated with inhibition of COX, which converts arachidonic acid to the prostaglandin precursor prostaglandin H2.
Product Categories/Family for anti-cko1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57,229 Da
NCBI Official Full Name
cytokinin dehydrogenase 1
NCBI Official Synonym Full Names
cytokinin oxidase1
NCBI Official Symbol
cko1
NCBI Official Synonym Symbols
cko; ckx1
NCBI Protein Information
cytokinin dehydrogenase 1; CKO 1; COX 1; zmCKX1; umc1057; umc1059; CL1532_1; p-umc1057; CL1532_1_ov; cytokinin oxidase
UniProt Protein Name
Cytokinin dehydrogenase 1
UniProt Gene Name
CKX1
UniProt Synonym Gene Names
CKO 1; COX 1
UniProt Entry Name
CKX1_MAIZE
Uniprot Description
Function: Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group. Cleaves zeatin, isopentenyladenine, isopentenyladenosine, zeatin riboside and cis-zeatin, but not dihydrozeatin, kinetin and benzylaminopurine.
Catalytic activity: N(6)-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced acceptor.
Cofactor: FAD.
Enzyme regulation: Competitive inhibition by phenylureas.
Subunit structure: Monomer
By similarity.
Subcellular location: Secreted › extracellular space.
Tissue specificity: Expressed in immature kernels and unpollinated cobs. Weakly expressed in kernels harvested two weeks after anthesis. Ref.3
Post-translational modification: Glycosylated; with approximately 10 hexose residues per site.
Sequence similarities: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.Contains 1 FAD-binding PCMH-type domain.
Research Articles on cko1
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Product Notes
The cko1 ckx1 (Catalog #AAA601329) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The COX 1 (Cyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1, Ovarian Cancer Marker) reacts with Bovine, Guinea Pig, Human, Rabbit, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's COX 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC). Suitable for use in ELISA and Immunohistochemistry. Not suitable for use in Western Blot. Researchers should empirically determine the suitability of the cko1 ckx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COX 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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