Mouse anti-Human, Mouse COTL1 Monoclonal Antibody | anti-COTL1 antibody

COTL1 Mouse Monoclonal

Cat. Num. AAA768121

• Gene Names: COTL1; CLP
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: COTL1; Monoclonal Antibody; COTL1 Mouse Monoclonal; anti-COTL1 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 142

• Applicable Applications for anti-COTL1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Coactosin-like 1 (Dictyostelium)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using MBS768121 (COTL1 Antibody) at dilution of 1:50)

Western Blot (WB)

(fetal human brain tissue were subjected to SDS PAGE followed by western blot with MBS768121 (COTL1 Antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 21624607
• NCBI GeneID: 23406
• NCBI Accession #: NP_066972.1
• NCBI GenBank Nucleotide #: NM_021149.3
• Molecular Weight: 15,945 Da
• NCBI Official Full Name: coactosin-like protein
• NCBI Official Synonym Full Names: coactosin like F-actin binding protein 1
• NCBI Official Symbol: COTL1
• NCBI Official Synonym Symbols: CLP
• NCBI Protein Information: coactosin-like protein
• UniProt Protein Name: Coactosin-like protein
• Protein Family: Coactosin-like protein
• UniProt Gene Name: COTL1
• UniProt Synonym Gene Names: CLP
• UniProt Entry Name: COTL1_HUMAN

NCBI Description

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

Uniprot Description

COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoplasm; cytoskeleton; nucleus

Molecular Function: actin binding; enzyme binding; protein binding

Biological Process: defense response to fungus