Western Blot (WB)
(Western blot detection of COTL1 in MCF7 and C6 cell lysates using COTL1 mouse mAb (1:1000 diluted).Predicted band size:16KDa.Observed band size:16KDa.)
Mouse anti-Human, Rat COTL1 Monoclonal Antibody | anti-COTL1 antibody
Anti-COTL1 Mouse mAb
Western Blot (WB)
(Western blot detection of COTL1 in MCF7 and C6 cell lysates using COTL1 mouse mAb (1:1000 diluted).Predicted band size:16KDa.Observed band size:16KDa.)
Western Blot (WB)
(Western blot detection of COTL1 in MCF7 and C6 cell lysates using COTL1 mouse mAb (1:1000 diluted).Predicted band size:16KDa.Observed band size:16KDa.)
Western Blot (WB)
(Western blot analysis using COTL1 mAb against HEK293 (1) and COTL1 (AA)
Western Blot (WB)
(Western blot analysis using COTL1 mAb against HEK293 (1) and COTL1 (AA)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded breast cancer tissues using COTL1 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded breast cancer tissues using COTL1 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded liver cancer tissues using COTL1 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded liver cancer tissues using COTL1 mouse mAb with DAB staining.)
UniPort Summary Function: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
Uniprot Description
COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 16q24.1
Molecular Function: actin binding; enzyme binding; protein binding
Research Articles on COTL1
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Product Notes
The COTL1 cotl1 (Catalog #AAA476258) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-COTL1 Mouse mAb reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's COTL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the COTL1 cotl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COTL1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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