Mouse anti-Human COPS6 Monoclonal Antibody | anti-COPS6 antibody

COPS6 (COP9 Signalosome Complex Subunit 6, Signalosome Subunit 6, SGN6, JAB1-Containing Signalosome Subunit 6, hVIP, Vpr-interacting Protein, MOV34 Homolog, CSN6, HVIP) (HRP)

Cat. Num. AAA6151919

• Gene Names: COPS6; CSN6; MOV34-34KD
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: COPS6; Monoclonal Antibody; COPS6 (COP9 Signalosome Complex Subunit 6; Signalosome Subunit 6; SGN6; JAB1-Containing Signalosome Subunit 6; hVIP; Vpr-interacting Protein; MOV34 Homolog; CSN6; HVIP) (HRP); anti-COPS6 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 2H5
• Specificity: Recognizes human COPS6.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).

• Applicable Applications for anti-COPS6 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 1.5ug/ml; Applications are based on unconjugated antibody.
• Immunogen: Partial recombinant corresponding to aa30-327 from human COPS6 (AAH02520) with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: VMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCN
• Conjugate: HRP
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Immunoperoxidase of monoclonal antibody to COPS6 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5ug/ml].)

Product Categories/Family for anti-COPS6 antibody

Antibodies; Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 33876807
• NCBI GeneID: 10980
• Molecular Weight: 36,163 Da
• NCBI Official Full Name: Homo sapiens COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis), mRNA
• NCBI Official Synonym Full Names: COP9 signalosome subunit 6
• NCBI Official Symbol: COPS6
• NCBI Official Synonym Symbols: CSN6; MOV34-34KD
• NCBI Protein Information: COP9 signalosome complex subunit 6

NCBI Description

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]