Mouse Complement C6 Monoclonal Antibody | anti-C6 antibody

Complement C6 antibody

• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Complement C6 antibody was purified by ammonium sulfate precipitation
• Synonyms: Complement C6; Monoclonal Antibody; Complement C6 antibody; Monoclonal Complement C6; Anti-Complement C6; C6; complement component 6; complement component C6; sixth complement component; anti-C6 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b kappa
• Clone Number: 13H5
• Purity/Purification: Complement C6 antibody was purified by ammonium sulfate precipitation
• Form/Format: Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 934

• Applicable Applications for anti-C6 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: 1:2000; IP: 2 ul
• Biological Significance: The sixth component of complement, C6, is a 913 amino acid single polypeptide chain serum glycoprotein. Homology study suggests that C6 could contain two domains, an amino-terminal region that is related to complement C8 and C9, and a carboxyl-terminal region that has partial homology to the complement regulatory proteins factor H and factor I. Genetic deficiencies of terminal complement components lead to markedly increased susceptibility to only one particular Gram-negative genus, the Neisseria. The susceptibility is attributable to the major role played by complement-mediated killing in host defense against the pathogen.
• Cross-Reactivity: Human
• Immunogen: Complement C6 antibody was raised in Mouse using a protein purified from Human plasma as the immunogen
• Preparation and Storage: Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

Western Blot (WB)

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Related Product Information for anti-C6 antibody

Mouse monoclonal Complement C6 antibody

Product Categories/Family for anti-C6 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 189242612
• NCBI GeneID: 729
• NCBI Accession #: NP_001108603.2
• NCBI GenBank Nucleotide #: NM_001115131.2
• UniProt Accession #: P13671
• Molecular Weight: 104,786 Da
• NCBI Official Full Name: complement component C6
• NCBI Official Synonym Full Names: complement component 6
• NCBI Official Symbol: C6
• NCBI Protein Information: complement component C6
• UniProt Protein Name: Complement component C6
• Protein Family: Complement component
• UniProt Gene Name: C6
• UniProt Entry Name: CO6_HUMAN

NCBI Description

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]

Uniprot Description

C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Molecular Function: protein binding

Biological Process: positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; in utero embryonic development; cytolysis; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 6 Deficiency