Mouse anti-Mouse, Rat COL2A1 Monoclonal Antibody | anti-COL2A1 antibody

COL2A1 Monoclonal Antibody

Cat. Num. AAA2556313

• Gene Names: Col2a1; Dmm; Lpk; Col2; Del1; Col2a; Col2a-1; M100413; Rgsc413; Rgsc856
• Reactivity: Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: COL2A1; Monoclonal Antibody; COL2A1 Monoclonal Antibody; Alpha 1 type II collagen; Alpha-1 type II collagen; AOM; Cartilage collagen; Chondrocalcin; CO2A1; COL11A3; Col2a1; Collagen II alpha 1 polypeptide; SEDC; anti-COL2A1 antibody

• Host: Mouse
• Reactivity: Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 2F12D3
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

• Applicable Applications for anti-COL2A1 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:300-1:1000
• Immunogen: Recombinant protein corresponding to Mouse collagen II
• Conjugation: Unconjugated
• NOTE: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20°C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded mouse bone using COL2A1 Monoclonal Antibody at dilution of 1:400.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded rat bone using COL2A1 Monoclonal Antibody at dilution of 1:300.)

Related Product Information for anti-COL2A1 antibody

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the Cpropeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Product Categories/Family for anti-COL2A1 antibody

Cancer; Signal transduction; Stem cells

NCBI and Uniprot Product Information

• NCBI GI #: 169658375
• NCBI GeneID: 12824
• NCBI Accession #: NP_001106987.2
• NCBI GenBank Nucleotide #: NM_001113515.2
• UniProt Accession #: P28481; Q61428; Q62031; Q62032; Q62033; Q641K3; Q6LDB1; Q6LDI8; Q6LDI9; Q80VY3; Q80X38; Q8CEF7
• NCBI Official Full Name: collagen alpha-1(II) chain isoform 2
• NCBI Official Synonym Full Names: collagen, type II, alpha 1
• NCBI Official Symbol: Col2a1
• NCBI Official Synonym Symbols: Dmm; Lpk; Col2; Del1; Col2a; Col2a-1; M100413; Rgsc413; Rgsc856
• NCBI Protein Information: collagen alpha-1(II) chain
• UniProt Protein Name: Collagen alpha-1(II) chain
• UniProt Gene Name: Col2a1

NCBI Description

This gene encodes the alpha-1 subunit of the fibril-forming type II collagen, the major component of cartilage and the vitreous humor of the eye. The encoded preproprotein forms homotrimeric, triple helical procollagen that undergoes proteolytic processing during fibirl formation. Mice harboring certain mutations in this gene exhibit severe chondrodysplasia characterized by short limbs and trunch, craniofacial deformities and cleft palate. A complete lack of the encoded protein in mice results in postnatal lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Dec 2015]

Uniprot Description

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.