Western Blot (WB)
(CNOT4 Antibody western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CNOT4 antibody detected the CNOT4 protein (arrow).)
Mouse anti-Human, mouse CNOT4 Monoclonal Antibody | anti-CNOT4 antibody
CNOT4 Antibody
Western Blot (WB)
(CNOT4 Antibody western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CNOT4 antibody detected the CNOT4 protein (arrow).)
Western Blot (WB)
(CNOT4 Antibody western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CNOT4 antibody detected the CNOT4 protein (arrow).)
Western Blot (WB)
(CNOT4 Antibody western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the CNOT4 antibody detected the CNOT4 protein (arrow).)
Western Blot (WB)
(CNOT4 Antibody western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the CNOT4 antibody detected the CNOT4 protein (arrow).)
CCR4-NOT complex, a global transcriptional regulator. The encoded
protein interacts with CNOT1 and has E3 ubiquitin ligase activity.
Several transcript variants encoding different isoforms have been
found for this gene.
Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)
Mersman, D.P., et al. Genes Dev. 23(8):951-962(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Winkler, G.S., et al. J. Mol. Biol. 337(1):157-165(2004)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Uniprot Description
CNOT4: Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: nucleus; cytosol; CCR4-NOT complex
Molecular Function: protein binding; zinc ion binding; nucleotide binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: poly(A) tail shortening; protein autoubiquitination; gene expression; mRNA catabolic process, deadenylation-dependent decay
Research Articles on CNOT4
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Product Notes
The CNOT4 cnot4 (Catalog #AAA9200499) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CNOT4 Antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CNOT4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:100~500. Researchers should empirically determine the suitability of the CNOT4 cnot4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNOT4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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