Mouse anti-Human CMTM6 Monoclonal Antibody | anti-CMTM6 antibody

SensiStain Anti-CMTM6 Antibody

Cat. Num. AAA4160489

• Gene Names: CMTM6; CKLFSF6; PRO2219
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Protein A/G Affinity Purified
• Synonyms: CMTM6; Monoclonal Antibody; SensiStain Anti-CMTM6 Antibody; anti-CMTM6 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: ACH0275
• Specificity: Human CMTM6
• Purity/Purification: Protein A/G Affinity Purified
• Form/Format: Liquid. PBS, pH7.4 with 0.02% Sodium Azide
• Concentration: 100ug/100ul (varies by lot)

• Applicable Applications for anti-CMTM6 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:1000-1:3000; ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human PD-L1
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing.; Expiration date is one (1) year from date of receipt.; Shipping Condition: Ice Packs

Related Product Information for anti-CMTM6 antibody

CMTM6, also referred to as CKLF Like MARVEL Transmembrane Domain Containing 6, is widely expressed in many tissues, but the function relatively remains unknown. SensiStain Anti- CMTM6 Antibody detects the presence of CMTM6 which can be found binding to PD-L1 and maintains its cell surface expression. Studies have showed that due to the binding to PD-L1, CMTM6 co-localizes at plasma membrane and recycling endosomes preventing PD-L1 from being targeted for lysosome-mediated degradation. Due to the high specificity CMTM6 has with PD-L1, it can be studied alongside with PD-L1 as it has a role in suppression of tumour-specific T cell activity.

Product Categories/Family for anti-CMTM6 antibody

Primary Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 8923370
• NCBI GeneID: 54918
• NCBI Accession #: NP_060271.1
• NCBI GenBank Nucleotide #: NM_017801.2
• UniProt Accession #: Q9NX76; Q6IAC4
• Molecular Weight: 20,419 Da
• NCBI Official Full Name: CKLF-like MARVEL transmembrane domain-containing protein 6
• NCBI Official Synonym Full Names: CKLF-like MARVEL transmembrane domain containing 6
• NCBI Official Symbol: CMTM6
• NCBI Official Synonym Symbols: CKLFSF6; PRO2219
• NCBI Protein Information: CKLF-like MARVEL transmembrane domain-containing protein 6; chemokine-like factor superfamily 6; chemokine-like factor super family 6; chemokine-like factor superfamily member 6
• UniProt Protein Name: CKLF-like MARVEL transmembrane domain-containing protein 6
• Protein Family: CKLF-like MARVEL transmembrane domain-containing protein
• UniProt Gene Name: CMTM6
• UniProt Synonym Gene Names: CKLFSF6
• UniProt Entry Name: CKLF6_HUMAN

NCBI Description

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

Uniprot Description

CMTM6: a member of the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, integral; Cytokine; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: extracellular space; membrane; integral to membrane

Molecular Function: cytokine activity

Biological Process: chemotaxis