anti-Human CK-MM Monoclonal Antibody | anti-CK-MM antibody

Anti-CK-MM Mouse mAb

Cat. Num. AAA475323

• Gene Names: CKM; CKMM; M-CK
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified
• Synonyms: CK-MM; Monoclonal Antibody; Anti-CK-MM Mouse mAb; CKM; CKMM; Creatine kinase M; Creatine kinase M chain; Creatine kinase M type; Creatine kinase M-type; Creatine kinase muscle; Creatine kinase; muscle type; KCRM_HUMAN; M-CK; MCK; Muscle creatine kinase; anti-CK-MM antibody

• Host: Mouse; Source: Human
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 6A12-C8
• Purity/Purification: Affinity Purified
• Form/Format: PBS (pH 7.4) containing with 0.03% Proclin300.
• Concentration: 4.84mg/ml (varies by lot)
• Sequence Length: 381

• Applicable Applications for anti-CK-MM antibody: ELISA (EIA)
• Immunogen: Purified recombinant human CK-MM protein expressed in E Coli.
• Sensitivity: This antibody detects Human CK-MM.
• Sequence Similarities: Belongs to the ATP:guanido phosphotransferase family. Contains 1 phosphagen kinase C-terminal domain. Contains 1 phosphagen kinase N-terminal domain.
• Subunit Structure: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
• Subcellular Location: Cytoplasm.

ELISA

(Indirect ELISA assay for anti-CK-MM mouse mAb.CKBB as control antigen. Antigen coating concentration: 4ug/ml.)

Related Product Information for anti-CK-MM antibody

Entrez Summary: There are 3 isoenzymes of creatine kinase (CK)-BB, MM, and MB. The primary source of CKMB is myocardium, although it is also found in skeletal muscle. CKMB levels increase with myocardial damage. Extreme elevations of CKMB can also be associated with skeletal muscle cell turnover as in polymyositis and to a lesser degree in rhabdomyolysis. It can also be elevated in cases of carbon monoxide poisoning, crush injuries, pulmonary embolism, hypothyroidism, and muscular dystrophy. While CKMB has been replaced by troponin assays in the workup of many patients with acute chest pain, CKMB may be useful if the initial troponin determination is abnormal or if a hospitalized patient has a suspected reinfarction.

NCBI and Uniprot Product Information

• NCBI GI #: 21536288
• NCBI GeneID: 1158
• NCBI Accession #: NP_001815.2
• NCBI GenBank Nucleotide #: NM_001824
• UniProt Accession #: P06732; Q96QL9
• Molecular Weight: 43,101 Da
• NCBI Official Full Name: creatine kinase M-type
• NCBI Official Synonym Full Names: creatine kinase, M-type
• NCBI Official Symbol: CKM
• NCBI Official Synonym Symbols: CKMM; M-CK
• NCBI Protein Information: creatine kinase M-type
• UniProt Protein Name: Creatine kinase M-type
• UniProt Gene Name: CKM
• UniProt Synonym Gene Names: CKMM

NCBI Description

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

Uniprot Description

CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function: creatine kinase activity; protein binding

Biological Process: creatine metabolic process