Rabbit anti-Human CIB2  Monoclonal Antibody | anti-CIB2  antibody

Rabbit anti Human CIB2  Monoclonal Antibody

Cat. Num. AAA2544381

• Gene Names: CIB2; KIP2; USH1J; DFNB48
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Synonyms: CIB2 ; Monoclonal Antibody; Rabbit anti Human CIB2 Monoclonal Antibody; anti-CIB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 192

• Applicable Applications for anti-CIB2 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CIB2. The detection limit for Human CIB2 is approximately 0.00975 ng/well.; IHC-P: 0.2-1 mug/mL
• Immunogen: Recombinant Human CIB2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 669033270
• NCBI GeneID: 10518
• NCBI GenBank Nucleotide #: NM_001301224.1
• Molecular Weight: 15,816 Da
• NCBI Official Full Name: calcium and integrin-binding family member 2 isoform 4
• NCBI Official Synonym Full Names: calcium and integrin binding family member 2
• NCBI Official Symbol: CIB2
• NCBI Official Synonym Symbols: KIP2; USH1J; DFNB48
• NCBI Protein Information: calcium and integrin-binding family member 2
• UniProt Protein Name: Calcium and integrin-binding family member 2
• UniProt Gene Name: CIB2
• UniProt Synonym Gene Names: KIP2; KIP 2
• UniProt Entry Name: CIB2_HUMAN

NCBI Description

The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction process

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: cytoplasm; photoreceptor inner segment; photoreceptor outer segment; stereocilium

Molecular Function: calcium ion binding; magnesium ion binding; protein binding; protein homodimerization activity

Biological Process: calcium ion homeostasis; elevation of cytosolic calcium ion concentration; photoreceptor cell maintenance

Disease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij