Mouse Cellular Retinoic Acid binding Protein 1 Monoclonal Antibody | anti-CRABP1 antibody
Mouse Anti Human Cellular Retinoic Acid binding Protein 1
Gene Names
CRABP1; RBP5; CRABP; CRABPI; CRABP-I
Applications
ELISA, Western Blot
Purity
CRABP1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Synonyms
Cellular Retinoic Acid binding Protein 1; Monoclonal Antibody; Mouse Anti Human Cellular Retinoic Acid binding Protein 1; CRABP1 Antibody; Mouse Anti Human; Cellular retinoic acid-binding protein 1; Cellular retinoic acid-binding protein I; CRABP-I; CRABP1; RBP5; CRABP; CRABPI; anti-CRABP1 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2b heavy chain and kappa light chain
Clone Number
PAT1A1AT
Purity/Purification
CRABP1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Form/Format
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sequence Length
137
Applicable Applications for anti-CRABP1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
CRABP1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1000. Recommended starting dilution is 1:500.
Immunogen
Anti-human CRABP1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CRABP1 amino acids 1-137 purified from E Coli.
Preparation and Storage
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
12 months at -20 degree C. 1 month at 4 degree C.
Related Product Information for anti-CRABP1 antibody
Introduction: CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though, CRABP1 is structurally similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior. Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore, frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma.
Product Categories/Family for anti-CRABP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15,566 Da
NCBI Official Full Name
cellular retinoic acid-binding protein 1
NCBI Official Synonym Full Names
cellular retinoic acid binding protein 1
NCBI Official Symbol
CRABP1
NCBI Official Synonym Symbols
RBP5; CRABP; CRABPI; CRABP-I
NCBI Protein Information
cellular retinoic acid-binding protein 1; cellular retinoic acid-binding protein I
UniProt Protein Name
Cellular retinoic acid-binding protein 1
Protein Family
UniProt Gene Name
CRABP1
UniProt Synonym Gene Names
RBP5; CRABP-I
UniProt Entry Name
RABP1_HUMAN
NCBI Description
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
Uniprot Description
CRABP1: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Chromosomal Location of Human Ortholog: 15q24
Cellular Component: cytosol
Molecular Function: retinoid binding; protein binding; retinoic acid binding; transporter activity; retinol binding; retinal binding
Biological Process: transport; multicellular organismal development; signal transduction
Research Articles on CRABP1
Similar Products
Product Notes
The CRABP1 crabp1 (Catalog #AAA140233) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Cellular Retinoic Acid binding Protein 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). CRABP1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1000. Recommended starting dilution is 1:500. Researchers should empirically determine the suitability of the CRABP1 crabp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cellular Retinoic Acid binding Protein 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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