Rat anti-Mouse CD62L Monoclonal Antibody | anti-CD62L antibody
Anti-Mouse CD62L Monoclonal Antibody (FITC Conjugated)
Gene Names
Sell; Lnhr; CD62L; Ly-22; Lyam1; Ly-m22; Lyam-1; LECAM-1; AI528707; L-selectin
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Synonyms
CD62L; Monoclonal Antibody; Anti-Mouse CD62L Monoclonal Antibody (FITC Conjugated); L-selectin; Sell; CD62 antigen-like family member L; LAM-1; LECAM1; Lymph node homing receptor; Ly-22; Lnhr; Ly22; anti-CD62L antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
Mel14
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Sequence Length
372
Applicable Applications for anti-CD62L antibody
Flow Cytometry (FC/FACS)
Conjugation
FITC
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
Related Product Information for anti-CD62L antibody
CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte "rolling" on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.
References
1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Kishimoto TK, et al. 1990. P. Natl. Acad. Sci. USA 87:2244. 3. Tedder TF, et al. 1995. J. Exp. Med. 181:2259.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42,288 Da
NCBI Official Full Name
L-selectin isoform 1
NCBI Official Synonym Full Names
selectin, lymphocyte
NCBI Official Symbol
Sell
NCBI Official Synonym Symbols
Lnhr; CD62L; Ly-22; Lyam1; Ly-m22; Lyam-1; LECAM-1; AI528707; L-selectin
NCBI Protein Information
L-selectin
UniProt Protein Name
L-selectin
UniProt Gene Name
Sell
UniProt Synonym Gene Names
Lnhr; Ly-22; Ly22; Ly-221 PublicationManual assertion based on opinion iniRef.2
Uniprot Description
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes (PubMed:1693096). Promotes initial tethering and rolling of leukocytes in endothelia ().
Research Articles on CD62L
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Product Notes
The CD62L sell (Catalog #AAA2556406) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mouse CD62L Monoclonal Antibody (FITC Conjugated) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD62L can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CD62L sell for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD62L, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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