Testing Data
(Figure A. FITC conjugated Mouse anti Rat CD61 and Alexa Fluor 647 conjugated Mouse IgG1 isotype control . Figure B. FITC conjugated Mouse anti Rat CD61 and Alexa Fluor 647 conjugated Mouse anti Human CD62E/CD62P and PE conjugated Mouse IgG1 isotype control . Figure B. FITC conjugated Mouse anti Human CD61 and PE conjugated Mouse anti Human CD62E/CD62P (MBS226119). All experiments perfo)
Mouse anti-Human CD62E/CD62P Monoclonal Antibody | anti-CD62E/CD62P antibody
Mouse anti Human CD62E/CD62P:RPE
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
5% Sucrose
Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
After reconstitution store at +4 degree C.
DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use
Testing Data
(Figure A. FITC conjugated Mouse anti Rat CD61 and Alexa Fluor 647 conjugated Mouse IgG1 isotype control . Figure B. FITC conjugated Mouse anti Rat CD61 and Alexa Fluor 647 conjugated Mouse anti Human CD62E/CD62P and PE conjugated Mouse IgG1 isotype control . Figure B. FITC conjugated Mouse anti Human CD61 and PE conjugated Mouse anti Human CD62E/CD62P (MBS226119). All experiments perfo)
Testing Data
(Figure A. FITC conjugated Mouse anti Rat CD61 and Alexa Fluor 647 conjugated Mouse IgG1 isotype control . Figure B. FITC conjugated Mouse anti Rat CD61 and Alexa Fluor 647 conjugated Mouse anti Human CD62E/CD62P and PE conjugated Mouse IgG1 isotype control . Figure B. FITC conjugated Mouse anti Human CD61 and PE conjugated Mouse anti Human CD62E/CD62P (MBS226119). All experiments perfo)
Although initially thought to recognize only human CD62E, more recent data (Goda et al. 2003) shows that Mouse anti Human CD62E/CD62P antibody, clone 1.2B6 also recognizes human CD62P, binding to a common epitope shared by these members of the selectin family.
Clone 1.2B6 reacts with porcine E-selectin (CD62E) but not with porcine P-selectin (Stocker et al. 2000).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Uniprot Description
SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q22-q25
Cellular Component: cortical cytoskeleton; extracellular space; perinuclear region of cytoplasm; integral to membrane; plasma membrane; coated pit; caveola; lipid raft
Molecular Function: protein binding; phospholipase binding; transmembrane receptor activity; sialic acid binding
Biological Process: heterophilic cell adhesion; leukocyte adhesion; phospholipase C activation; positive regulation of leukocyte migration; actin filament-based process; positive regulation of receptor internalization; regulation of inflammatory response; calcium-mediated signaling; response to lipopolysaccharide; blood coagulation; leukocyte tethering or rolling; inflammatory response; leukocyte migration; leukocyte migration during inflammatory response
Disease: Hypertension, Essential
Research Articles on CD62E/CD62P
Similar Products
Product Notes
The CD62E/CD62P sele (Catalog #AAA226119) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Human CD62E/CD62P:RPE reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD62E/CD62P can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). FC/FACS: Neat. Researchers should empirically determine the suitability of the CD62E/CD62P sele for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD62E/CD62P, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
