Mouse anti-Human CD41 Monoclonal Antibody | anti-CD41 antibody

CD41 (CD41 Antigen, CD41b, gp2b, GPalphaIIb, GPIIb, Gta, HPA3, HPA-3, Integrin alpha IIb, Integrin alpha 2b, ITGA2B, ITGAB, Platelet Glycoprotein IIb of IIb/IIIa Complex, Platelet Fibrinogen Receptor alpha, Platelet Membrane Glycoprotein IIb, Platelet spe

Cat. Num. AAA6247624

• Gene Names: ITGA2B; GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16
• Reactivity: Human
• Purity: Purified by protein G affinity chromatography from tissue culture supernatant.
• Synonyms: CD41; Monoclonal Antibody; CD41 (CD41 Antigen; CD41b; gp2b; GPalphaIIb; GPIIb; Gta; HPA3; HPA-3; Integrin alpha IIb; Integrin alpha 2b; ITGA2B; ITGAB; Platelet Glycoprotein IIb of IIb/IIIa Complex; Platelet Fibrinogen Receptor alpha; Platelet Membrane Glycoprotein IIb; Platelet spe; Antigen CD41; anti-CD41 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 3H1299
• Specificity: Recognizes human CD41. Not established if this antibody recognizes free human CD41 or human CD41 only when complexed with CD61. Antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex. Species Crossreactivity: baboon, mink and mustelid.
• Purity/Purification: Purified by protein G affinity chromatography from tissue culture supernatant.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phosphatase.

• Immunogen: Human platelet plasma membrane.
• Conjugate: AP
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Testing Data

(Staining of human peripheral blood platelets with moue anti-human CD4 (ALEXA 647).)

Testing Data

(Staining of human peripheral blood platelets with C2394-04E.)

Testing Data

(Staining of human peripheral blood platelets with C2394-04F.)

Testing Data

(Staining of human peripheral blood platelets with C2394-04G.)

Product Categories/Family for anti-CD41 antibody

Antibodies; CD Markers

References

1. Hornby, E.J. et al. (1991) Activation of human platelets by exposure to a monoclonal, PM6/248, to glycoprotein IIb-IIIa. Br. J. Haematol. 79: 277-285. 2. Michelson, A.D. et al. (1995) A panel of platelet mAb for the study of haemostasis and thrombosis in baboons. Leukocyte Typing V. Oxford University Press p 1230-1231. 3. Maloney, S.F. ety al. (2010) P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Integr Biol (Camb). 2: 183-92. 4. Aasted, B. et al. (2007) Reactivity of monoclonal antibodies to human CD antigens with cells from mink. Vet Immunol Immunopathol. 119: 27-37. 5. Massoudy, P. et al. (2001) Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass. Chest. 119: 31-6. 6. Kahng, J. et al. (2008) Quantitative comparisons of antibody-binding sites of platelet glycoprotein IIb/IIIa in aplastic anemia and idiopathic thrombocytopenic purpura. Ann Clin Lab Sci. 38: 6-11. 7. Chae, H. et al. (2009) EDTA Inhibits the Binding of Clone 96.2C1, an Anti-CD41a Monoclonal Antibody, to the Platelets and Addition of Heparin and CaCl2 to the Antibody Neutralizes the EDTA-induced Inhibitory Effect Korean J Hematol 44: 42 - 6. 8. Zahler, S. et al. (1999) Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass. Cardiovasc Res. 41: 722-30. 9. Wang, J.S. et al. (2005) Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men. Arterioscler Thromb Vasc Biol. 25: 454-60. 10. Welsh, J.D. et al. (2012) Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. J Thromb Haemost. Sep 15.

NCBI and Uniprot Product Information

• NCBI GI #: 88758615
• NCBI GeneID: 3674
• NCBI Accession #: NP_000410.2
• NCBI GenBank Nucleotide #: NM_000419.3
• UniProt Accession #: P08514; O95366; Q14443; Q17R67; B2RCY8
• Molecular Weight: 1039
• NCBI Official Full Name: integrin alpha-IIb preproprotein
• NCBI Official Synonym Full Names: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
• NCBI Official Symbol: ITGA2B
• NCBI Official Synonym Symbols: GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16
• NCBI Protein Information: integrin alpha-IIb; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit
• UniProt Protein Name: Integrin alpha-IIb
• UniProt Gene Name: ITGA2B
• UniProt Synonym Gene Names: GP2B; ITGAB; GPIIb
• UniProt Entry Name: ITA2B_HUMAN