Mouse anti-Human CD370 Monoclonal Antibody | anti-CD370 antibody
Anti-CD370 Purified
Gene Names
CLEC9A; CD370; DNGR1; DNGR-1; UNQ9341
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
CD370; Monoclonal Antibody; Anti-CD370 Purified; C-type lectin domain containing 9A; CLEC9A; DNGR1; DNGR-1; UNQ9341; anti-CD370 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
8F9
Specificity
The mouse monoclonal antibody 8F9 recognizes an extracellular epitope of CD370 / CLEC9A (DNGR1), a type II transmembrane protein functioning as an endocytic receptor on BDCA31+ dendritic cells and on a subset of CD14+ CD16- monocytes.
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
241
Applicable Applications for anti-CD370 antibody
Flow Cytometry (FC/FACS), Immunocytochemistry (ICC)
Application Notes
FC/FACS: QC tested
Immunogen
RBL-2H3 cells expressing human CLEC9A fused to an HA epitope
Preparation and Storage
Store at 2-8 degree C.
Related Product Information for anti-CD370 antibody
CD370 / CLEC9A, also known as DNGR1, is a type II transmembrane glycoprotein with extracellular C-type lectin domain and intracellular ITAM-containing domain. Its expression is restricted to BDCA3+ conventional dendritic cells and to a subset of CD14+ CD16- monocytes. CD370 serves as a receptor for ubiquitous preformed acid-labile protein associated ligands that are exposed when the cell membrane is damaged, such as on necrotic cells. Its triggering by these ligands mediates recruitment and activation of the tyrosine kinase Syk and leads to their cross-presentation to the immune system.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
C-type lectin domain family 9 member A
NCBI Official Synonym Full Names
C-type lectin domain containing 9A
NCBI Official Symbol
CLEC9A
NCBI Official Synonym Symbols
CD370; DNGR1; DNGR-1; UNQ9341
NCBI Protein Information
C-type lectin domain family 9 member A
UniProt Protein Name
C-type lectin domain family 9 member A
UniProt Gene Name
CLEC9A
UniProt Entry Name
CLC9A_HUMAN
NCBI Description
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
Uniprot Description
CLEC9A: Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: cell surface; integral to membrane
Molecular Function: carbohydrate binding
Biological Process: receptor-mediated endocytosis; positive regulation of cytokine secretion
Research Articles on CD370
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Product Notes
The CD370 clec9a (Catalog #AAA1800297) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD370 Purified reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD370 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunocytochemistry (ICC). FC/FACS: QC tested. Researchers should empirically determine the suitability of the CD370 clec9a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD370, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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