Hamster CD28 Monoclonal Antibody | anti-CD28 antibody

Hamster Anti Mouse CD28 FITC

Cat. Num. AAA140138

• Purity: Protein-A.
• Synonyms: CD28; Monoclonal Antibody; Hamster Anti Mouse CD28 FITC; CD28 Antibody; FITC; Hamster Anti-Mouse; CD28 FITC; anti-CD28 antibody

• Host: Hamster
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: NYRmCD28
• Purity/Purification: Protein-A.
• Concentration: 1mg/ml in PBS (after reconstitution). (varies by lot)
• Sequence Length: 218

• Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
• Immunogen: Purified mouse purified mouse LN T cells.
• Antibody Properties: Blocking and staining antibody. For staining, use 10 ul/1,000,000 cells. Titer for blocking T cell activation should be determined by the investigator.
• Available Conjugates: This antibody is only available non-conjugated to Biotin.
• Preparation and Storage: Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.

Related Product Information for anti-CD28 antibody

Introduction: CD28 co-stimulation is necessary for CD4 positive T-cell proliferation & survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence.

Product Categories/Family for anti-CD28 antibody

Monoclonal Antibodies; Anti-Mouse Lymphocytes; Monoclonal Antibodies; Anti Mouse Lymphocyte

NCBI and Uniprot Product Information

• NCBI GI #: 161484597
• NCBI GeneID: 12487
• NCBI Accession #: NP_031668.3
• NCBI GenBank Nucleotide #: NM_007642.4
• Molecular Weight: 25,243 Da
• NCBI Official Full Name: T-cell-specific surface glycoprotein CD28
• NCBI Official Synonym Full Names: CD28 antigen
• NCBI Official Symbol: Cd28
• NCBI Protein Information: T-cell-specific surface glycoprotein CD28
• UniProt Protein Name: T-cell-specific surface glycoprotein CD28
• Protein Family: T-cell-specific surface glycoprotein
• UniProt Gene Name: Cd28
• UniProt Entry Name: CD28_MOUSE

Uniprot Description

CD28: a type I plasma membrane protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Binds to B7-1 and -2. Expressed in T cells and plasma cells, but not in less mature B cells. Six splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: membrane; plasma membrane; integral to membrane; immunological synapse; lipid raft; external side of plasma membrane

Molecular Function: protein homodimerization activity; protease binding; SH3/SH2 adaptor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; positive regulation of mitosis; T cell activation; positive regulation of interleukin-2 biosynthetic process; negative thymic T cell selection; T cell receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of inflammatory response to antigenic stimulus; positive regulation of protein kinase B signaling cascade; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of T cell proliferation; immune response; positive regulation of alpha-beta T cell proliferation; regulatory T cell differentiation