Mouse CD26 Monoclonal Antibody | anti-CD26 antibody

MOUSE ANTI BOVINE CD26

Cat. Num. AAA212250

• Gene Names: DPP4; CD26; DPPIV
• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation
• Synonyms: CD26; Monoclonal Antibody; MOUSE ANTI BOVINE CD26; anti-CD26 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: CC69
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 765

• Applicable Applications for anti-CD26 antibody: Flow cytometry (FC/FACS), Immunoprecipitation (IP)
• Application Notes: Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. ; Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/200
• Perservative Stabilisers: 0.09% Sodium Azide; Preparation
• Buffer Solution: Phosphate buffered saline
• Target Species: Bovine
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-CD26 antibody

Mouse anti Bovine CD26 antibody, clone CC69 recognizes bovine Dipeptidyl peptidase 4, also known as CD26, WC10, Adenosine deaminase complexing protein or Activation molecule 3 (Lee et al. 2001). Bovine CD26 is a 765 amino acid single pass type II transmembrane glycoprotein which can be cleaved between residues 37-38 to release a soluble form of the protein. CD26 can exist as a monomer, forms a homodimer for optimal dipeptidase activity or it can form a heterodimer with seprase (UniProt: P81425). CD26 is expressed by a subpopulation of CD2+ T cells, dendritic cells and weakly by most B cells and is also seen on some non-haematopoietic cells, especially gut epithelium. Myeloid cells and the majority of WC1+ve T cells do not express CD26.

NCBI and Uniprot Product Information

• NCBI GI #: 27806655
• NCBI GeneID: 281122
• NCBI Accession #: NP_776464.1
• NCBI GenBank Nucleotide #: NM_174039.2
• UniProt Accession #: P81425; Q3ZCC2; Q8WMG8
• Molecular Weight: 88,369 Da
• NCBI Official Full Name: dipeptidyl peptidase 4
• NCBI Official Symbol: DPP4
• NCBI Official Synonym Symbols: CD26; DPPIV
• NCBI Protein Information: dipeptidyl peptidase 4; ACT3; ADCP-I; DPP IV; T-cell activation antigen CD26; WC10; activation molecule 3; adenosine deaminase complexing protein; dipeptidyl peptidase IV; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
• UniProt Protein Name: Dipeptidyl peptidase 4
• UniProt Gene Name: DPP4
• UniProt Synonym Gene Names: CD26; ACT3; ADCP-I; DPP IV
• UniProt Entry Name: DPP4_BOVIN

Uniprot Description

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.