Rat anti-Murine CD24 Monoclonal Antibody | anti-CD24 antibody

CD24 antibody (Spectral Red)

Cat. Num. AAA532281

• Gene Names: CD24; CD24A
• Reactivity: Murine
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry
• Synonyms: CD24; Monoclonal Antibody; CD24 antibody (Spectral Red); Monoclonal CD24; Anti-CD24; CD 24; HSA; CD-24; anti-CD24 antibody

• Host: Rat
• Reactivity: Murine
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 91
• Specificity: Murine
• Form/Format: Supplied as a liquid in PBS, with NaN3 added as preservative.
• Concentration: 0.1 mg/ml (varies by lot)
• Sequence Length: 80

• Applicable Applications for anti-CD24 antibody: Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)
• Biological Significance: Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene. CD24 is a cell adhesion molecule. CD24 is a glycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 3p26, 15q21, 15q22, 20q11.2 and Yq11.1. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Tag/Conjugate: Spectral Red
• Immunogen: CD24 antibody (Spectral Red) was raised in rat using murine heat stable antigen as the immunogen.
• Preparation and Storage: Store at 4 degree C.

Related Product Information for anti-CD24 antibody

Rat monoclonal CD24 antibody (Spectral Red)

Product Categories/Family for anti-CD24 antibody

Immunology; Conjugated Monoclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 209405388
• NCBI GeneID: 100133941
• UniProt Accession #: P25063; Q16257; Q53XS0
• Molecular Weight: 8,097 Da
• NCBI Official Full Name: CD24
• NCBI Official Synonym Full Names: CD24 molecule
• NCBI Official Symbol: CD24
• NCBI Official Synonym Symbols: CD24A
• NCBI Protein Information: signal transducer CD24
• UniProt Protein Name: Signal transducer CD24
• Protein Family: Signal transducer
• UniProt Gene Name: CD24
• UniProt Synonym Gene Names: CD24A
• UniProt Entry Name: CD24_HUMAN

NCBI Description

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Description

CD24: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS). A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Belongs to the CD24 family.

Protein type: Membrane protein, GPI anchor; Cell development/differentiation; Cell surface; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cell surface; membrane; plasma membrane; lipid raft

Molecular Function: protein binding; signal transducer activity; protein tyrosine kinase activator activity; protein kinase binding

Biological Process: respiratory burst; axon guidance; cell migration; Wnt receptor signaling pathway; regulation of phosphorylation; B cell receptor transport into lipid raft; immune response-regulating cell surface receptor signaling pathway; chemokine receptor transport out of lipid raft; positive regulation of activated T cell proliferation; cell activation; positive regulation of MAP kinase activity; elevation of cytosolic calcium ion concentration; cell-cell adhesion; cholesterol homeostasis; response to estrogen stimulus; regulation of MAPKKK cascade; response to molecule of bacterial origin; T cell costimulation; negative regulation of transforming growth factor-beta3 production; regulation of epithelial cell differentiation; response to hypoxia; regulation of cytokine and chemokine mediated signaling pathway

Disease: Multiple Sclerosis, Susceptibility To