Mouse CD23 Monoclonal Antibody | anti-CD23 antibody

CD23 Mouse Monoclonal Antibody

Cat. Num. AAA9400059

• Gene Names: FCER1G; FCRG
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity purification using immunogen.
• Synonyms: CD23; Monoclonal Antibody; CD23 Mouse Monoclonal Antibody; Fc fragment of IgE; high affinity I; receptor for; Fc-epsilon RI-gamma; FCER1G; FCERG; anti-CD23 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Clone Number: 1E9
• Specificity: The CD23 antibody detects endogenous CD23 proteins.
• Purity/Purification: Affinity purification using immunogen.
• Form/Format: Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 86

• Applicable Applications for anti-CD23 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:200
• Target Name: CD23
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(IHC staining of paraffin-embedded Human tonsil tissue with CD23 mouse mAb ¨1E9 ©diluted at 1:200.)

Related Product Information for anti-CD23 antibody

The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils.

Product Categories/Family for anti-CD23 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4758344
• NCBI GeneID: 2207
• NCBI Accession #: NP_004097.1
• NCBI GenBank Nucleotide #: NM_004106.1
• UniProt Accession #: P30273; Q5VTW4
• Molecular Weight: 9,667 Da
• NCBI Official Full Name: high affinity immunoglobulin epsilon receptor subunit gamma
• NCBI Official Synonym Full Names: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
• NCBI Official Symbol: FCER1G
• NCBI Official Synonym Symbols: FCRG
• NCBI Protein Information: high affinity immunoglobulin epsilon receptor subunit gamma
• UniProt Protein Name: High affinity immunoglobulin epsilon receptor subunit gamma
• UniProt Gene Name: FCER1G
• UniProt Synonym Gene Names: FcRgamma; FceRI gamma
• UniProt Entry Name: FCERG_HUMAN

NCBI Description

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

FCER1G: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. Belongs to the CD3Z/FCER1G family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: cell surface; integral to plasma membrane; Fc-epsilon receptor I complex; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; IgG binding; IgE binding; IgE receptor activity

Biological Process: integrin-mediated signaling pathway; platelet activation; neutrophil chemotaxis; positive regulation of type I hypersensitivity; positive regulation of interleukin-6 production; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of mast cell degranulation; positive regulation of type III hypersensitivity; positive regulation of tumor necrosis factor production; mast cell activation; positive regulation of interleukin-10 production; neutrophil activation during immune response; negative regulation of mast cell apoptosis; serotonin secretion by platelet; positive regulation of type IIa hypersensitivity; positive regulation of phagocytosis; defense response to bacterium; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immunoglobulin mediated immune response; positive regulation of mast cell cytokine production; Fc receptor mediated stimulatory signaling pathway; blood coagulation; phagocytosis, engulfment; leukocyte migration