Rabbit anti-Mouse CD23 Monoclonal Antibody | anti-FCER2 antibody

Recombinant Anti-CD23 Antibody (PE), Rabbit Monoclonal

Cat. Num. AAA8111928

• Gene Names: Fcer2a; CD23; Fce2; Fcer2; Ly-42
• Reactivity: Mouse
• Applications: Flow Cytometry, Functional Assay
• Purity: Protein A
• Synonyms: CD23; Monoclonal Antibody; Recombinant Anti-CD23 Antibody (PE); Rabbit Monoclonal; CD23/FCER2 Antibody (PE); Rabbit MAb; Fc fragment of IgE receptor II; Anti-CD23 Antibody; Anti-Fce2 Antibody; Anti-Fcer2 Antibody; Anti-Fcer2a Antibody; Anti-Ly-42 Antibody; anti-FCER2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 007
• Specificity: Mouse CD23/FCER2
• Purity/Purification: Protein A
• Form/Format: Liquid; Aqueous solution containing 0.5% BSA and 0.09% sodium azide
• Concentration: 2ul/Test, 0.1mg/ml (varies by lot)

• Applicable Applications for anti-FCER2 antibody: Flow Cytometry (FC/FACS/FCM)
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Mouse CD23/FCER2 protein
• Conjugation: PE
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD23/FCER2 (rM CD23/FCER2) and conjugated with PE under optimum conditions, the unreacted PE was removed.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of mouse FCER2(CD23) expression on mouse splenocytes. BABL/c splenocytes were stained with PE-conjugated anti-Mouse FCER2(CD23). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable cells.)

Related Product Information for anti-FCER2 antibody

Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor).

Product Categories/Family for anti-FCER2 antibody

Fc Receptors ITIM/ITAM Immunoreceptors and Related Molecules

References

Aubry JP, et al. (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature. 358(6386): 505-7.Punnonen J, et al. (1993) Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A. 90(8): 3730-4.Yu P, et al. (1994) Negative feedback regulation of IgE synthesis by murine CD23. Nature. 369(6483): 753-6.

NCBI and Uniprot Product Information

• NCBI GI #: 18476522
• NCBI GeneID: 14128
• UniProt Accession #: P20693; Q61556; Q61557
• Molecular Weight: 37,648 Da
• NCBI Official Full Name: Fc epsilon receptor II subtype b variant b delta 6
• NCBI Official Synonym Full Names: Fc receptor, IgE, low affinity II, alpha polypeptide
• NCBI Official Symbol: Fcer2a
• NCBI Official Synonym Symbols: CD23; Fce2; Fcer2; Ly-42
• NCBI Protein Information: low affinity immunoglobulin epsilon Fc receptor; FC epsilon RII; fc-epsilon-RII; lymphocyte IgE receptor; low-affinity IgE receptor
• UniProt Protein Name: Low affinity immunoglobulin epsilon Fc receptor
• Protein Family: Low affinity immunoglobulin epsilon Fc receptor
• UniProt Gene Name: Fcer2
• UniProt Synonym Gene Names: Fcer2a
• UniProt Entry Name: FCER2_MOUSE

Uniprot Description

FCER2: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: metal ion binding; IgE binding; carbohydrate binding

Biological Process: positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of nitric-oxide synthase activity; positive regulation of killing of cells of another organism; positive regulation of nitric-oxide synthase biosynthetic process