Hamster anti-Mouse CD209b Monoclonal Antibody | anti-CD209b antibody
Purified Anti-Mouse CD209b Monoclonal Antibody
Gene Names
Cd209b; OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation
Synonyms
CD209b; Monoclonal Antibody; Purified Anti-Mouse CD209b Monoclonal Antibody; Mouse CD209b; CD209 antigen-like protein B; Cd209b; DC-SIGN-related protein 1; DC-SIGNR1; OtB7; CD209; anti-CD209b antibody
Host
Hamster
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG
Clone Number
22D1
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Sequence Length
295
Applicable Applications for anti-CD209b antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <=0.5 ug per 10e6 cells in 100 ul volume or 100 ul of whole blood.
Conjugation
Unconjugated
Cellular Localization
Membrane
Preparation and Storage
Store at 2-8 degree C. Protected from prolonged exposure to light.
Related Product Information for anti-CD209b antibody
CD209B, also known as SIGN-R1, is a mouse C-type lectin receptor predominantly expressed on macrophages in the spleen marginal zone and lymph nodes medulla. CD209B is a mouse homolog of human CD209/DC-SIGN and is involved in innate immune response. CD209B mediates the recognition and uptake of pathogen products, such as lipopolysaccharides (LPS), pneumococcal polysaccharides, and dextrans. CD209B has been demonstrated to facilitate the clearance of encapsulated pneumococcus by directly binding to C1q and activating complement through an immunoglobulin independent pathway.
References
1. Zhou Y, et al. 2010. Nat. Med. 16:1128. 2. Saunders SP, et al. 2010. J. Immunol. 184:2627. 3. Silva-Martin N, et al. 2009. Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 65:1264. 4. Saunders SP, et al. 2009. Infect. Immun. 77:399. 5. Park JY, et al. 2009. Neurosci. Lett. 450:246. 6. Lanoue A, et al. J. Exp. Med. 200:1383.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
33,889 Da
NCBI Official Full Name
CD209 antigen-like protein B isoform b
NCBI Official Synonym Full Names
CD209b antigen
NCBI Official Symbol
Cd209b
NCBI Official Synonym Symbols
OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
NCBI Protein Information
CD209 antigen-like protein B
UniProt Protein Name
CD209 antigen-like protein B
Protein Family
UniProt Gene Name
Cd209b
UniProt Synonym Gene Names
DC-SIGNR1
Uniprot Description
Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.MiscellaneousIn vitro, is a receptor for HIV-1, HIV-2 and SIV, but does not transmit virus to permissive T-cells under the conditions tested.CautionIn mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified.
Research Articles on CD209b
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Product Notes
The CD209b cd209b (Catalog #AAA2553785) is an Antibody produced from Hamster and is intended for research purposes only. The product is available for immediate purchase. The Purified Anti-Mouse CD209b Monoclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD209b can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP). Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <=0.5 ug per 10e6 cells in 100 ul volume or 100 ul of whole blood. Researchers should empirically determine the suitability of the CD209b cd209b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD209b, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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