Mouse anti-Human CD1a Monoclonal Antibody | anti-CD1a antibody

Anti-Human CD1a Monoclonal Antibody (PerCP/Cyanine5.5 Conjugated) [OKT-6]

Cat. Num. AAA2558918

• Gene Names: CD1A; R4; T6; CD1; FCB6; HTA1
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Synonyms: CD1a; Monoclonal Antibody; Anti-Human CD1a Monoclonal Antibody (PerCP/Cyanine5.5 Conjugated) [OKT-6]; Human CD1a; T6; R4; CD 1a; CD1A; T-cell surface glycoprotein CD1a; anti-CD1a antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: OKT-6
• Form/Format: PBS with 0.05% Proclin300, 1% BSA
• Sequence Length: 327

• Applicable Applications for anti-CD1a antibody: Flow Cytometry (FC/FACS)
• Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 2 muL or 5 muL of antibody per test (million cells in 100 ul staining volume or per 100 ul of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
• Conjugation: PerCP/Cyanine5.5
• Isotype Control: Mouse IgG1, kappa Isotype Control (PerCP/Cy5.5 Conjugated)
• Preparation and Storage: Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.

Flow Cytometry (FC/FACS)

(Human T lymphoblastic leukemia cell line Molt-4 are stained with Anti-Human CD1a Monoclonal Antibody(PerCP/Cyanine5.5 Conjugated)(filled gray histogram) or Mouse IgG1 Isotype Control PerCP/Cy5.5(empty black histogram).)

Related Product Information for anti-CD1a antibody

CD1a is a 49 kD member of the immunoglobulin superfamily also known as T6 and R4. It is a type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with beta2-microglobulin. CD1a plays a role in non-peptide glycolipid antigen presentation to CD1-restricted T cells. It is expressed on cortical double positive and single positive thymocytes, Langerhans cells, and dendritic cells. In addition to antigen presentation, CD1a has been implicated in thymic T cell development.

NCBI and Uniprot Product Information

• NCBI GI #: 288558852
• NCBI GeneID: 909
• UniProt Accession #: P06126
• NCBI Official Full Name: T-cell surface glycoprotein CD1a
• NCBI Official Synonym Full Names: CD1a molecule
• NCBI Official Symbol: CD1A
• NCBI Official Synonym Symbols: R4; T6; CD1; FCB6; HTA1
• NCBI Protein Information: T-cell surface glycoprotein CD1a
• UniProt Protein Name: T-cell surface glycoprotein CD1a
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD1A
• UniProt Synonym Gene Names: hTa1 thymocyte antigen

NCBI Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.