Mouse anti-Human CD183 Monoclonal Antibody | anti-CD183 antibody

Anti-Human CD183 Monoclonal Antibody (FITC Conjugated)

Cat. Num. AAA2559137

• Gene Names: CXCR3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
• Reactivity: Human
• Applications: Flow Cytometry
• Synonyms: CD183; Monoclonal Antibody; Anti-Human CD183 Monoclonal Antibody (FITC Conjugated); CXCR3; GPR9; CXC-R3; CXCR-3; CKR-L2; anti-CD183 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1, k
• Clone Number: G025H7
• Form/Format: Liquid; PBS with 0.05% Proclin 300, 1% BSA

• Applicable Applications for anti-CD183 antibody: Flow Cytometry (FC)
• Isotype Control: FITC Mouse IgG1, Isotype Control[MOPC-21] [Product MBS2557731]
• Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 ul staining volume or per 100ul of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions mustbe determined for individual use.
• Important Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Keep as concentrated solution.; Store at 2~8°C and protected from prolonged exposure to light.; Do not freeze.

Fluorophore

(Conjugation: FITC)

Related Product Information for anti-CD183 antibody

Human CXCR3, also known as GPR9, is a chemokine receptor that binds CXCL9, CXCL10, and CXCL11. It is a 38 kD seven-pass transmembrane receptor coupled to G-protein. CXCR3 is highly expressed by T cells (Th1), natural killer cells (NK cells), dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. CXCR3 is important for effector lymphocyte recruitment into inflamed tissue in various inflammatory and autoimmune diseases, such as chronically inflamed liver, Crohn's disease, rheumatoid arthritis, multiple sclerosis, and inflammatory skin diseases.

NCBI and Uniprot Product Information

• NCBI GI #: 218563730
• NCBI GeneID: 2833
• NCBI Accession #: NP_001136269.1
• NCBI GenBank Nucleotide #: NP_001136269.1
• UniProt Accession #: P49682
• NCBI Official Full Name: C-X-C chemokine receptor type 3 isoform 2
• NCBI Official Synonym Full Names: C-X-C motif chemokine receptor 3
• NCBI Official Symbol: CXCR3
• NCBI Official Synonym Symbols: GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
• NCBI Protein Information: C-X-C chemokine receptor type 3
• UniProt Protein Name: C-X-C chemokine receptor type 3
• UniProt Gene Name: CXCR3
• UniProt Synonym Gene Names: GPR9; CXC-R3; CXCR-3
• UniProt Entry Name: CXCR3_HUMAN

NCBI Description

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Uniprot Description

CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: C-X-C chemokine binding; chemokine binding; chemokine receptor activity; receptor activity; C-X-C chemokine receptor activity

Biological Process: apoptosis; positive regulation of chemotaxis; calcium-mediated signaling; positive regulation of cAMP metabolic process; chemotaxis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; negative regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of leukocyte migration; negative regulation of endothelial cell proliferation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of release of sequestered calcium ion into cytosol; angiogenesis; cell motility; inflammatory response; cell adhesion