Flow Cytometry (FC/FACS)
(Mouse abdominal macrophages elicited by starch broth are stained with Anti-Mouse CD14 Monoclonal Antibody(PE/Cyanine7 Conjugated)(filled gray curve). Unstained macrophages (blank black curve) are used as control.)
Rat anti-Mouse CD14 Monoclonal Antibody | anti-CD14 antibody
Anti-Mouse CD14 Monoclonal Antibody (PE/Cyanine7 Conjugated) [Sa14-2]
Flow Cytometry (FC/FACS)
(Mouse abdominal macrophages elicited by starch broth are stained with Anti-Mouse CD14 Monoclonal Antibody(PE/Cyanine7 Conjugated)(filled gray curve). Unstained macrophages (blank black curve) are used as control.)
Flow Cytometry (FC/FACS)
(Mouse abdominal macrophages elicited by starch broth are stained with Anti-Mouse CD14 Monoclonal Antibody(PE/Cyanine7 Conjugated)(filled gray curve). Unstained macrophages (blank black curve) are used as control.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]
Uniprot Description
CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
Protein type: Membrane protein, GPI anchor
Cellular Component: anchored to external side of plasma membrane; cell surface; external side of plasma membrane; extracellular space; Golgi apparatus; lipid raft; lipopolysaccharide receptor complex; plasma membrane
Molecular Function: lipopolysaccharide binding
Biological Process: inflammatory response; lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine secretion; positive regulation of endocytosis; positive regulation of interferon type I production; positive regulation of interferon-gamma production; positive regulation of tumor necrosis factor production; receptor-mediated endocytosis; response to bacterium; response to molecule of bacterial origin; toll-like receptor 4 signaling pathway
Research Articles on CD14
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Product Notes
The CD14 cd14 (Catalog #AAA2559241) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti-Mouse CD14 Monoclonal Antibody (PE/Cyanine7 Conjugated) [Sa14-2] reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD14 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2 ug per 106 cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Researchers should empirically determine the suitability of the CD14 cd14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD14, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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