Rat anti-Mouse CD132 Monoclonal Antibody | anti-CD132 antibody
Purified Anti-Mouse CD132 Monoclonal Antibody
Gene Names
Il2rg; gc; p64; [g]c; CD132; gamma(c)
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Synonyms
CD132; Monoclonal Antibody; Purified Anti-Mouse CD132 Monoclonal Antibody; Mouse CD132; Cytokine receptor common subunit gamma; Il2rg; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; anti-CD132 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
3E12
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Sequence Length
369
Applicable Applications for anti-CD132 antibody
Flow Cytometry (FC/FACS)
Application Notes
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <=2.0 ug per 10e6 cells in 100 ul volume or 100 ul of whole blood.
Conjugation
Unconjugated
Cellular Localization
Membrane
Preparation and Storage
Store at 2-8 degree C. Protected from prolonged exposure to light.
Related Product Information for anti-CD132 antibody
CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common gamma chain (gammac) or IL-2 receptor gamma subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).
References
1. Itano M, et al. 1996. Tohoku J. Exp. Med. 178:389. 2. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication. 3. Nakarai T, et al. 1994. J. Exp. Med. 180:241. 4. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724. 5. Habib T, et al. 2002. Biochemistry. 41:8725. 6. Matthews DJ, et al. 1995. Blood 85:38.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42,241 Da
NCBI Official Full Name
cytokine receptor common subunit gamma isoform a
NCBI Official Synonym Full Names
interleukin 2 receptor, gamma chain
NCBI Official Symbol
Il2rg
NCBI Official Synonym Symbols
gc; p64; [g]c; CD132; gamma(c)
NCBI Protein Information
cytokine receptor common subunit gamma
UniProt Protein Name
Cytokine receptor common subunit gamma
UniProt Gene Name
Il2rg
UniProt Synonym Gene Names
IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG
NCBI Description
This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Uniprot Description
Common subunit for the receptors for a variety of interleukins.
Research Articles on CD132
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Product Notes
The CD132 il2rg (Catalog #AAA2553775) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Purified Anti-Mouse CD132 Monoclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD132 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <=2.0 ug per 10e6 cells in 100 ul volume or 100 ul of whole blood. Researchers should empirically determine the suitability of the CD132 il2rg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD132, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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