Mouse anti-Human CD105 Monoclonal Antibody
Mouse Anti-Human CD105-UNLB
Reactivity
Human
Applications
Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Synonyms
CD105; Monoclonal Antibody; Mouse Anti-Human CD105-UNLB; Mouse Anti-Human CD105; anti-CD105 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
SN6
Specificity
Human CD105
CD105, also known as endoglin, is a 95 kDa type II transmembrane glycoprotein that is expressed on the cell surface as a disulfide-linked homodimer and is found on endothelial cells. CD105 is one of several receptors for the various isoforms of TGFbeta, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control on the immune response.1-8
CD105, also known as endoglin, is a 95 kDa type II transmembrane glycoprotein that is expressed on the cell surface as a disulfide-linked homodimer and is found on endothelial cells. CD105 is one of several receptors for the various isoforms of TGFbeta, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control on the immune response.1-8
Form/Format
Purified (UNLB) Antibody
Applicable Applications for anti-CD105 antibody
Flow Cytometry, Immunohistochemistry (Frozen sections), Immunoprecipitation
Application Notes
Flow Cytometry: <= 1 ug/10^6 cells
Characterization
To insure lot-to-lot consistency, each batch of product is tested by immunohistochemistry and/or flow cytometry to conform with the characteristics of a standard reference reagent.
Warning
Reagents contain sodium azide which is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Preparation and Storage
The purified (UNLB) antibody is supplied as 0.1 mg purified immunoglobulin in 0.5 mL of phosphate buffered saline containing 0.1% PBS/NaN3. Store at 2-8 degree C.
References
1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford.
2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD105 Section, Academic Press, New York, p. 384.
3. Lastres, P., T. Bellon, C. Cabanas, F. Martin-Perez, A. Acevedo, A. Gougos, M. Letarte, and C. Bernabeu. 1992. Eur. J. Immunol. 22:393.
4. Lopez-Casilias, F., S. Cheifetz, J. Doody, J.L. Andres, W.S. Lane, and J. Massague. 1991. Cell 67:785.
5. Fernandez-Ruiz, E., S. St-Jacques, T. Bellon, M. Letarte, and C. Bernabeu. 1993 Cytogonet. Cell Genet. 64:204.
6. 231. Bellon, T., A. Corbi, P. Lastres, C. Cales, M. Cebrian, S. Vera, S. Cheifetz, J. Massague, M. Letarte, and C. Bernabeu. 1993. Eur. J. Immunol. 23:2340.
7. Lastres, P., J. Martin-Perez, C. Langa, and C. Bernabeu. 1994. Biochem. J. 301:765.
8. Westenend, P.J., et al. 1994. J. Am. Soc. Neph. 5:822.
2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD105 Section, Academic Press, New York, p. 384.
3. Lastres, P., T. Bellon, C. Cabanas, F. Martin-Perez, A. Acevedo, A. Gougos, M. Letarte, and C. Bernabeu. 1992. Eur. J. Immunol. 22:393.
4. Lopez-Casilias, F., S. Cheifetz, J. Doody, J.L. Andres, W.S. Lane, and J. Massague. 1991. Cell 67:785.
5. Fernandez-Ruiz, E., S. St-Jacques, T. Bellon, M. Letarte, and C. Bernabeu. 1993 Cytogonet. Cell Genet. 64:204.
6. 231. Bellon, T., A. Corbi, P. Lastres, C. Cales, M. Cebrian, S. Vera, S. Cheifetz, J. Massague, M. Letarte, and C. Bernabeu. 1993. Eur. J. Immunol. 23:2340.
7. Lastres, P., J. Martin-Perez, C. Langa, and C. Bernabeu. 1994. Biochem. J. 301:765.
8. Westenend, P.J., et al. 1994. J. Am. Soc. Neph. 5:822.
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Product Notes
The CD105 (Catalog #AAA670205) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human CD105-UNLB reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD105 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry, Immunohistochemistry (Frozen sections), Immunoprecipitation. Flow Cytometry: <= 1 ug/10^6 cells. Researchers should empirically determine the suitability of the CD105 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD105, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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