Rat anti-Mouse CCR9 Monoclonal Antibody | anti-CCR9 antibody

CCR9 (C-C chemokine receptor type 9, CC-CKR-9, C-C CKR-9, CCR-9, CDw199, GPR28, GPR-9-6, G-protein coupled receptor 28)

Cat. Num. AAA607361

• Gene Names: CCR9; GPR28; CDw199; GPR-9-6
• Reactivity: Mouse
• Applications: Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: CCR9; Monoclonal Antibody; CCR9 (C-C chemokine receptor type 9; CC-CKR-9; C-C CKR-9; CCR-9; CDw199; GPR28; GPR-9-6; G-protein coupled receptor 28); Anti -CCR9 (C-C chemokine receptor type 9; anti-CCR9 antibody

• Host: Rat
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 10B2187
• Specificity: Recognizes mouse CDw199.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.

• Applicable Applications for anti-CCR9 antibody: Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Flow Cytometry.; Dilution: Flow Cytometry: 1:25-1:200; 10ul labels 10e6 cells in 100ul
• Immunogen: 25 aa from the amino terminal of murine CCR9, coupled to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

(Staining of mouse thymocytes with unconjugated Rat anti Mouse CDw199)

Testing Data

(Staining of mouse thymocytes with Rat anti Mouse CDw199:FITC)

Testing Data

(Staining of mouse thymocytes with Rat anti Mouse CDw199:Alexa Fluor ®488)

Testing Data

(Staining of mouse thymocytes with unconjugated Rat anti Mouse CDw199:RPE)

Testing Data

(Staining of mouse thymocytes with Rat anti Mouse CDw199:Alexa Fluor ®647)

Product Categories/Family for anti-CCR9 antibody

Antibodies; Abs to G Protein Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 14043044
• NCBI GeneID: 10803
• NCBI Accession #: NP_006632.2
• NCBI GenBank Nucleotide #: NM_006641.3
• UniProt Accession #: P51686; Q4VBM3; Q549E0; Q9UQQ6; Q9UN87
• Molecular Weight: 42,016 Da
• NCBI Official Full Name: C-C chemokine receptor type 9 isoform B
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 9
• NCBI Official Symbol: CCR9
• NCBI Official Synonym Symbols: GPR28; CDw199; GPR-9-6
• NCBI Protein Information: C-C chemokine receptor type 9; CC-CKR-9; OTTHUMP00000164653; OTTHUMP00000164654; G protein-coupled receptor 28
• UniProt Protein Name: C-C chemokine receptor type 9
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR9
• UniProt Synonym Gene Names: GPR28
• UniProt Entry Name: CCR9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. [provided by RefSeq]

Uniprot Description

CCR9: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cellular defense response; immune response; chemotaxis