Mouse anti-Human CCR2/CD192 Monoclonal Antibody | anti-CCR2/CD192 antibody

Anti-human CCR2/CD192 Monoclonal Antibody

Cat. Num. AAA418458

• Gene Names: CCR2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
• Reactivity: Human
• Purity: Affinity Purified
• Synonyms: CCR2/CD192; Monoclonal Antibody; Anti-human CCR2/CD192 Monoclonal Antibody; anti-CCR2/CD192 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a kappa
• Purity/Purification: Affinity Purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 360

• Immunogen: CR2bDEF3.L1/2 cells derived from the murine pre-B lymphoma cell line, L1/2, transfected with the human CCR2B cDNA coding region.
• Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Related Product Information for anti-CCR2/CD192 antibody

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

References

LaRosa GJ. Anti-CCR2 antibodies and methods of use therefor. US Patent 6, 312, 689 dated Nov 6 2001LaRosa GJ, et al. Anti-CCR2 antibodies and methods of use therefor. US Patent 6, 352, 832 dated Mar 5 2002LaRosa GJ. Method of inhibiting leukocyte trafficking by anti-CCR2 amino-terminal domain antibodies. US Patent 6, 395, 497 dated May 28 2002LaRosa GJ. Method of inhibiting interaction of cells bearing CCR2 by Anti-CCR2 amino-terminal domain antibodies. US Patent 6, 406, 865 dated Jun 18 2002LaRosa GJ. Anti-CCR2 antibodies. US Patent 6, 406, 694 dated Jun 18 2002LaRosa GJ. Method of inhibiting cell function associated with CCR2 by anti-CCR2 amino-terminal domain antibodies. US Patent 6, 448,021 dated Sep 10 2002LaRosa GJ. Anti-CCR2 antibodies and methods of use therefor. US Patent 6, 451,522 dated Sep 17 2002Anti-CCR2 antibodies and methods of use therefor. US Patent 6, 458, 353 dated Oct 1 2002LaRosa GJ. Anti-CCR2 antibodies and methods of use therefor. US Patent 6, 491, 915 dated Dec 10 2002

NCBI and Uniprot Product Information

• NCBI GI #: 183979982
• NCBI GeneID: 729230
• NCBI Accession #: NP_001116868.1
• NCBI GenBank Nucleotide #: NM_001123396.1
• UniProt Accession #: P41597; Q4VBL2; A0AVQ3; B2RMT0
• Molecular Weight: 41,064 Da
• NCBI Official Full Name: C-C chemokine receptor type 2 isoform B
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 2
• NCBI Official Symbol: CCR2
• NCBI Official Synonym Symbols: CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
• NCBI Protein Information: C-C chemokine receptor type 2
• UniProt Protein Name: C-C chemokine receptor type 2
• UniProt Gene Name: CCR2
• UniProt Synonym Gene Names: CMKBR2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; MCP-1-R

NCBI Description

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

Uniprot Description

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell soma; cytoplasm; cytosol; dendrite; integral to membrane; integral to plasma membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: CCR2 chemokine receptor binding; chemokine receptor activity; protein homodimerization activity

Biological Process: blood vessel remodeling; cellular calcium ion homeostasis; cellular defense response; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; JAK-STAT cascade; negative regulation of adenylate cyclase activity; negative regulation of angiogenesis; negative regulation of eosinophil degranulation; negative regulation of T-helper 2 type immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-2 production; positive regulation of T cell activation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor biosynthetic process; response to wounding