Mouse Casein Kinase II alpha Monoclonal Antibody | anti-CSNK2A1 antibody

Casein Kinase II alpha antibody

• Gene Names: CSNK2A1; CKII; CK2A1; CSNK2A3
• Applications: ELISA, Western Blot
• Purity: Casein Kinase II alpha antibody was purified by ammonium sulfate precipitation
• Synonyms: Casein Kinase II alpha; Monoclonal Antibody; Casein Kinase II alpha antibody; Monoclonal Casein Kinase II alpha; Anti-Casein Kinase II alpha; CSNK2A1; casein kinase 2; alpha 1 polypeptide; alpha subunit of casein kinase II; BOS_13292; casein kinase 2 protein catalytic subunit; casein kinase II; alpha 1 related sequence 4; casein kinase II alpha 1 subunit; casein kinase II alpha subunit; casein kinase II subunit alpha; Casein kinase II subunit alpha'; ck2a1; CK2 catalytic subunit alpha; CKII; CK II; CK II alpha; Csnk2a1-rs4; protein kinase CK2; RP23-452D3.3; anti-CSNK2A1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b kappa
• Clone Number: 27H4
• Purity/Purification: Casein Kinase II alpha antibody was purified by ammonium sulfate precipitation
• Form/Format: Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 391

• Applicable Applications for anti-CSNK2A1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:2000
• Biological Significance: The casein kinase I (CKI) family of serine/threonine protein kinases is highly conserved from yeast to humans. The CKI family is involved in many diverse and important cellular functions, such as regulation of membrane transport, cell division, DNA repair, circadian rhythms, and nuclear localization. The name of the enzyme family was originated from the convenience of casein as a substrate since the earliest days of research on protein phosphorylation.
• Cross-Reactivity: Human, Mouse, Rat
• Immunogen: Casein Kinase II alpha antibody was raised in Mouse using a recombinant human protein purified from E Coli(His-Casein kinase II a) as the immunogen
• Preparation and Storage: Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

Western Blot (WB)

()

Related Product Information for anti-CSNK2A1 antibody

Mouse monoclonal Casein Kinase II alpha antibody

Product Categories/Family for anti-CSNK2A1 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4503095
• NCBI GeneID: 1457
• NCBI Accession #: NP_001886.1
• NCBI GenBank Nucleotide #: NM_001895.3
• UniProt Accession #: P68400; P19138; P20426; Q14013; Q5U065; B4DYS6; D3DVV8; Q8NEV1
• Molecular Weight: 29,181 Da
• NCBI Official Full Name: casein kinase II subunit alpha isoform a
• NCBI Official Synonym Full Names: casein kinase 2, alpha 1 polypeptide
• NCBI Official Symbol: CSNK2A1
• NCBI Official Synonym Symbols: CKII; CK2A1; CSNK2A3
• NCBI Protein Information: casein kinase II subunit alpha
• UniProt Protein Name: Casein kinase II subunit alpha
• Protein Family: Casein kinase
• UniProt Gene Name: CSNK2A1
• UniProt Synonym Gene Names: CK2A1; CK II alpha
• UniProt Entry Name: CSK21_HUMAN

NCBI Description

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Description

CK2A1: an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB).

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Other group; CK2 family

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: Sin3 complex; plasma membrane; PcG protein complex; NuRD complex; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein N-terminus binding; Hsp90 protein binding; ATP binding

Biological Process: axon guidance; Wnt receptor signaling pathway; transcription, DNA-dependent; rhythmic process; negative regulation of caspase activity; signal transduction; positive regulation of cell growth; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of protein catabolic process; mitotic cell cycle; positive regulation of Wnt receptor signaling pathway