Mouse Cardiac Troponin I Monoclonal Antibody | anti-TNNI3 antibody

Cardiac Troponin I Monoclonal Antibody

Cat. Num. AAA190081

• Gene Names: TNNI3; CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; MGC116817
• Applications: Western Blot
• Synonyms: Cardiac Troponin I; Monoclonal Antibody; Cardiac Troponin I Monoclonal Antibody; Anti-Cardiac Troponin I; anti-TNNI3 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: Anti-Cardiac Troponin I [Murine MAbs recognize human cardiac troponin I and do not cross-react with human skeletal troponin (2 clones).]
• Form/Format: 100 ug Protein A-purified antibody in PBS, pH 7.4.
• Sequence Length: 210

• Applicable Applications for anti-TNNI3 antibody: Western Blot, Immunoassay
• Application Notes: These antibodies may be used in immunoassays and Western Blots to detect and quantitate human cardiac troponin I. They may also be used to affinity purify cardiac troponin I.
• Antigen: Purified human cardiac troponin I.
• Activity and Specificity: These antibodies react specifically with human cardiac troponin I. There is no cross-reactivity with human skeletal troponin I. ELISA titers > 1: 1,000,000.
• Stabilizer: None
• Preservatives: 0.1% sodium azide.
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles

Product Categories/Family for anti-TNNI3 antibody

Hormone and Serum Protein Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 1524066
• NCBI GeneID: 7137
• UniProt Accession #: P19429; Q6FGU5; Q6FGX2
• Molecular Weight: 24,008 Da
• NCBI Official Full Name: cardiac troponin I
• NCBI Official Synonym Full Names: troponin I type 3 (cardiac)
• NCBI Official Symbol: TNNI3
• NCBI Official Synonym Symbols: CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; MGC116817
• NCBI Protein Information: troponin I, cardiac muscle
• UniProt Protein Name: Troponin I, cardiac muscle
• Protein Family: Troponin
• UniProt Gene Name: TNNI3
• UniProt Synonym Gene Names: TNNC1
• UniProt Entry Name: TNNI3_HUMAN

NCBI Description

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq]

Uniprot Description

TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.

Protein type: Motor; Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: sarcomere; troponin complex; cytosol

Molecular Function: troponin T binding; protein domain specific binding; troponin C binding; protein binding; metal ion binding; calcium channel inhibitor activity; actin binding; calcium-dependent protein binding; protein kinase binding

Biological Process: cellular calcium ion homeostasis; regulation of smooth muscle contraction; heart contraction; heart development; regulation of systemic arterial blood pressure by ischemic conditions; ventricular cardiac muscle morphogenesis; vasculogenesis; negative regulation of ATPase activity; cardiac muscle contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Familial Restrictive, 1; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Dilated, 2a