Rabbit anti-Mouse CADM3/NECL1  Monoclonal Antibody | anti-CADM3/NECL1  antibody

Rabbit anti Mouse CADM3/NECL1  Monoclonal Antibody

Cat. Num. AAA2544588

• Gene Names: CADM3; BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: CADM3/NECL1 ; Monoclonal Antibody; Rabbit anti Mouse CADM3/NECL1 Monoclonal Antibody; anti-CADM3/NECL1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 398

• Applicable Applications for anti-CADM3/NECL1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse CADM3. The detection limit for Mouse CADM3 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Mouse CADM3/NECL1/IGSF4B Protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CADM3/NECL1/IGSF4B (rM CADM3/NECL1/IGSF4B; NP_444429.1; Met 1-His 328).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CADM3/NECL1  antibody

Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca (2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation.

NCBI and Uniprot Product Information

• NCBI GI #: 187608363
• NCBI GeneID: 57863
• NCBI GenBank Nucleotide #: NM_001127173.2
• Molecular Weight: 38,326 Da
• NCBI Official Full Name: cell adhesion molecule 3 isoform 2
• NCBI Official Synonym Full Names: cell adhesion molecule 3
• NCBI Official Symbol: CADM3
• NCBI Official Synonym Symbols: BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
• NCBI Protein Information: cell adhesion molecule 3
• UniProt Protein Name: Cell adhesion molecule 3
• UniProt Gene Name: CADM3
• UniProt Synonym Gene Names: IGSF4B; NECL1; SYNCAM3; TSLL1; IgSF4B; NECL-1; SynCAM3; TSLL1
• UniProt Entry Name: CADM3_HUMAN

NCBI Description

The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

Uniprot Description

CADM3: Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2-q22

Cellular Component: cell-cell adherens junction; integral to plasma membrane; intercellular junction; plasma membrane

Molecular Function: cell adhesion molecule binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion