Mouse BTN1A1 Monoclonal Antibody | anti-BTN1A1 antibody

BTN1A1 antibody

Cat. Num. AAA533757

• Gene Names: BTN1A1; BT; BTN; BTN1
• Applications: Flow Cytometry, Functional Assay, Immunofluorescence, Western Blot
• Purity: BTN1A1 antibody was purified by affinity chromatography.
• Synonyms: BTN1A1; Monoclonal Antibody; BTN1A1 antibody; Monoclonal BTN1A1; Anti-BTN1A1; Butyrophilin Subfamily 1 Member A1; BT; BTN; BTNA 1; BTNA-1; anti-BTN1A1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7C2
• Purity/Purification: BTN1A1 antibody was purified by affinity chromatography.
• Form/Format: Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 500 ug-1 mg/ml (varies by lot)
• Sequence Length: 526

• Applicable Applications for anti-BTN1A1 antibody: Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)
• Application Notes: FC: 1:100; IF: 1:100; WB: 1:2000
• Biological Significance: Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families. Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families.
• Cross-Reactivity: Human
• Immunogen: BTN1A1 antibody was raised in mouse using a full length recombinant protein of human BTN1A1 (NP_001723) produced in HEK293T cells, as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant BTN1A1 protein (Right) or empty vector (Left) detected with BTN1A1 antibody)

Immunofluorescence (IF)

(Immunofluorescent staining of COS7 cells transiently transfected with recombinant BTN1A1 protein using BTN1A1 antibody)

Related Product Information for anti-BTN1A1 antibody

Mouse monoclonal BTN1A1 antibody

Product Categories/Family for anti-BTN1A1 antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 166197658
• NCBI GeneID: 696
• NCBI Accession #: NP_001723
• NCBI GenBank Nucleotide #: NM_001732.2
• UniProt Accession #: Q13410; Q4VAN3; Q4VAN4; Q9H458
• Molecular Weight: 58,960 Da
• NCBI Official Full Name: butyrophilin subfamily 1 member A1
• NCBI Official Synonym Full Names: butyrophilin, subfamily 1, member A1
• NCBI Official Symbol: BTN1A1
• NCBI Official Synonym Symbols: BT; BTN; BTN1
• NCBI Protein Information: butyrophilin subfamily 1 member A1
• UniProt Protein Name: Butyrophilin subfamily 1 member A1
• Protein Family: Butyrophilin subfamily
• UniProt Gene Name: BTN1A1
• UniProt Synonym Gene Names: BTN; BT
• UniProt Entry Name: BT1A1_HUMAN

NCBI Description

Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families [provided by RefSeq, Jul 2008]

Uniprot Description

BTN1A1: May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin superfamily. BTN/MOG family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: receptor activity