Mouse anti-Human BTG1 Monoclonal Antibody | anti-BTG1 antibody

Mouse monoclonal antibody Anti-Human BTG1

Cat. Num. AAA120115

• Reactivity: Human
• Applications: Dot Blot
• Synonyms: BTG1; Monoclonal Antibody; Mouse monoclonal antibody Anti-Human BTG1; Homo sapiens B-cell translocation gene 1; anti-proliferative (BTG1); mRNA; anti-BTG1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2095C1a
• Concentration: 100 ug/ml (1.0 ml) (varies by lot)
• Sequence Length: 4704

• Applicable Applications for anti-BTG1 antibody: Dot Blot (DB)
• Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
• Sterility: Filtered through a 0.22 um membrane.

Quality Control

(Western blot analysis of immunized recombinant protein, using anti-BTG1 monoclonal antibody. )

Quality Control #2

(Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.)

Related Product Information for anti-BTG1 antibody

The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation. [NCBI Entrez Gene Summary]

NCBI and Uniprot Product Information

• NCBI GI #: 209447059
• NCBI GeneID: 694
• NCBI Accession #: NP_001722.1
• NCBI GenBank Nucleotide #: NM_001731
• Molecular Weight: 19,209 Da
• NCBI Official Full Name: Homo sapiens B-cell translocation gene 1, anti-proliferative (BTG1), mRNA
• NCBI Official Synonym Full Names: B-cell translocation gene 1, anti-proliferative
• NCBI Official Symbol: BTG1
• NCBI Protein Information: protein BTG1; B-cell translocation gene 1 protein
• Protein Family: Protein
• UniProt Gene Name: BTG1
• UniProt Entry Name: BTG1_HUMAN

NCBI Description

This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

Uniprot Description

BTG1: Anti-proliferative protein. A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC. Belongs to the BTG family.

Protein type: Oncoprotein; Cell cycle regulation

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; enzyme binding; transcription cofactor activity; kinase binding

Biological Process: negative regulation of cell proliferation; positive regulation of angiogenesis; cell migration; positive regulation of endothelial cell differentiation; regulation of transcription, DNA-dependent; negative regulation of cell growth; positive regulation of myoblast differentiation