Mouse anti-Human BRCA2 and CDKN1A-interacting Protein Monoclonal Antibody | anti-BCCIP antibody

BRCA2 and CDKN1A-interacting Protein (BCCIP, P21 and CDK-associated Protein 1, Protein TOK-1, TOK 1, TOK1)

Cat. Num. AAA605177

• Gene Names: BCCIP; TOK1; TOK-1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: BRCA2 and CDKN1A-interacting Protein; Monoclonal Antibody; BRCA2 and CDKN1A-interacting Protein (BCCIP; P21 and CDK-associated Protein 1; Protein TOK-1; TOK 1; TOK1); Anti -BRCA2 and CDKN1A-interacting Protein (BCCIP; anti-BCCIP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 9j23
• Specificity: Recognizes human BCCIP.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 1% BSA and 0.05% sodium azide.

• Applicable Applications for anti-BCCIP antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Synthetic peptide corresponding to the C-terminal region of human BCCIP
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-BCCIP antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 17402873
• NCBI GeneID: 56647
• NCBI Accession #: NP_510869.1
• NCBI GenBank Nucleotide #: NM_078469.2
• UniProt Accession #: Q9P287; Q8ND15; Q96GC4; Q9P288
• Molecular Weight: 35,979 Da
• NCBI Official Full Name: BRCA2 and CDKN1A-interacting protein isoform C
• NCBI Official Synonym Full Names: BRCA2 and CDKN1A interacting protein
• NCBI Official Symbol: BCCIP
• NCBI Official Synonym Symbols: TOK1; TOK-1
• NCBI Protein Information: BRCA2 and CDKN1A-interacting protein; BCCIPbeta; TOK-1beta; BCCIPalpha; TOK-1alpha; protein TOK-1; OTTHUMP00000020714; OTTHUMP00000020715; OTTHUMP00000020716; cdk inhibitor p21 binding protein; p21- and CDK-associated protein 1; BRCA2 and Cip1/p21 interacting protein
• UniProt Protein Name: BRCA2 and CDKN1A-interacting protein
• Protein Family: BRCA2 and CDKN1A-interacting protein
• UniProt Gene Name: BCCIP
• UniProt Synonym Gene Names: TOK1
• UniProt Entry Name: BCCIP_HUMAN

NCBI Description

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Uniprot Description

BCCIP: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). Belongs to the BCP1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q26.1

Cellular Component: nuclear cyclin-dependent protein kinase holoenzyme complex; nucleus

Molecular Function: protein binding; kinase regulator activity

Biological Process: regulation of cyclin-dependent protein kinase activity; DNA repair; cell cycle