Rat B7DC Monoclonal Antibody | anti-B7DC antibody
B7DC antibody
Applications
Functional Assay
Purity
B7DC antibody was purified by affinity chromatography.
Synonyms
B7DC; Monoclonal Antibody; B7DC antibody; Monoclonal B7DC; Anti-B7DC; PD-L2; BDC 7; PDL2; BDC-7; PDL-2; anti-B7DC antibody
Host
Rat
Clonality
Monoclonal
Isotype
IgG2a kappa
Clone Number
122
Specificity
Mouse
Purity/Purification
B7DC antibody was purified by affinity chromatography.
Form/Format
Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer.
Concentration
100 ug/ml (varies by lot)
Applicable Applications for anti-B7DC antibody
Functional Assay
Application Notes
The bioactivity of this protein was determined by transmigration assay of human T lymphocytes, with maximum chemotaxis observed at 100-200 ng/ml. The ED50 for this effect is less than or equal to 50 ng/ml, which corresponds to a specific activity of greater than or equal to 2 x 10e4 Units/mg.
Biological Significance
The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25 kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail. B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25, another mAb specific for mouse B7-DC.
Preparation and Storage
Store at 2-8 degree C. Do not freeze. Protect from light.
Related Product Information for anti-B7DC antibody
Rat monoclonal B7DC antibody
Product Categories/Family for anti-B7DC antibody
Similar Products
Product Notes
The B7DC (Catalog #AAA832926) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's B7DC can be used in a range of immunoassay formats including, but not limited to, Functional Assay. The bioactivity of this protein was determined by transmigration assay of human T lymphocytes, with maximum chemotaxis observed at 100-200 ng/ml. The ED50 for this effect is less than or equal to 50 ng/ml, which corresponds to a specific activity of greater than or equal to 2 x 10e4 Units/mg. Researchers should empirically determine the suitability of the B7DC for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "B7DC, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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