Mouse anti-Human, Mouse ARA9 Monoclonal Antibody | anti-AIP antibody

ARA9 (XAP2, Ah Receptor Associated Protein, ARA9, AIP)

Cat. Num. AAA604103

• Gene Names: AIP; ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Ascites; Ascities
• Synonyms: ARA9; Monoclonal Antibody; ARA9 (XAP2; Ah Receptor Associated Protein; AIP); Anti -ARA9 (XAP2; anti-AIP antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 3C108
• Specificity: Specific for ARA9 FKBP domain.
• Purity/Purification: Ascites; Ascities
• Form/Format: Supplied as a liquid.

• Applicable Applications for anti-AIP antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:1000. Band is seen at 37kD, representing ARA9
• Immunogen: Bacterially expressed human ARA9.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-AIP antibody

Ah receptor-associated protein (ARA9) is also known as AIP and XAP2. This protein displays structural similarity to the glucocorticoid receptor-associated immunophilin FKBP52. Although they share significant homology, they have distinct cellular roles and biochemical properties. ARA9 is known to affect the potency and efficacy of AHR agonists in the yeast Saccharomyces cerevisiae as well as having functional consequence on AHR signal transduction.

Product Categories/Family for anti-AIP antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 201860300
• NCBI GeneID: 9049
• NCBI Accession #: NP_003968.2
• NCBI GenBank Nucleotide #: NM_003977.2
• UniProt Accession #: O00170; Q2M3Q2; Q99606; A0SZW3; A0SZW4; A0SZW5; A0SZW6
• Molecular Weight: 37,636 Da
• NCBI Official Full Name: AH receptor-interacting protein
• NCBI Official Synonym Full Names: aryl hydrocarbon receptor interacting protein
• NCBI Official Symbol: AIP
• NCBI Official Synonym Symbols: ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• NCBI Protein Information: AH receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2
• UniProt Protein Name: AH receptor-interacting protein
• Protein Family: AH receptor-interacting protein
• UniProt Gene Name: AIP
• UniProt Synonym Gene Names: XAP2; AIP; XAP-2
• UniProt Entry Name: AIP_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008]

Uniprot Description

AIP: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: signal transducer activity; protein binding; transcription coactivator activity; unfolded protein binding; transcription factor binding

Biological Process: protein maturation via protein folding; xenobiotic metabolic process; signal transduction; protein targeting to mitochondrion; negative regulation of cyclic-nucleotide phosphodiesterase activity

Disease: Pituitary Adenoma, Prolactin-secreting; Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting