Mouse APOLIPOPROTEIN H Monoclonal Antibody | anti-APOH antibody

MOUSE ANTI HUMAN APOLIPOPROTEIN H

Cat. Num. AAA214131

• Gene Names: APOH; BG; B2G1; B2GP1
• Applications: Immunohistochemistry, Western Blot
• Synonyms: APOLIPOPROTEIN H; Monoclonal Antibody; MOUSE ANTI HUMAN APOLIPOPROTEIN H; anti-APOH antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: ID2
• Specificity: This item recognises the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1.This protein is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, which is a process involved in the pathogenesis of recurrent miscarriage (anti phospholipid syndrome).
• Form/Format: Tissue Culture Supernatant - liquid
• Sequence Length: 345

• Applicable Applications for anti-APOH antibody: Immunohistology Frozen, Western Blot (WB)
• Perservative Stabilisers: 0.09% Sodium Azide
• Histology Positive Control Tissue: Placenta
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data

(Staining of an 8.6 week placenta stained with Mouse anti Human Apolipoprotein H)

Related Product Information for anti-APOH antibody

MBS214131 recognises the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1.This protein is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, which is a process involved in the pathogenesis of recurrent miscarriage (anti phospholipid syndrome).

NCBI and Uniprot Product Information

• NCBI GI #: 153266841
• NCBI GeneID: 350
• NCBI Accession #: NP_000033.2
• NCBI GenBank Nucleotide #: NM_000042.2
• UniProt Accession #: P02749; Q9UCN7; B2R9M3
• Molecular Weight: 38,298 Da
• NCBI Official Full Name: beta-2-glycoprotein 1
• NCBI Official Synonym Full Names: apolipoprotein H (beta-2-glycoprotein I)
• NCBI Official Symbol: APOH
• NCBI Official Synonym Symbols: BG; B2G1; B2GP1
• NCBI Protein Information: beta-2-glycoprotein 1; APC inhibitor; B2GPI; activated protein C-binding protein; anticardiolipin cofactor; apo-H; beta(2)GPI
• UniProt Protein Name: Beta-2-glycoprotein 1
• Protein Family: Beta-2-glycoprotein
• UniProt Gene Name: APOH
• UniProt Synonym Gene Names: B2G1; Apo-H; B2GPI; Beta(2)GPI
• UniProt Entry Name: APOH_HUMAN

NCBI Description

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Uniprot Description

APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Lipid-binding; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface

Molecular Function: heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding

Biological Process: negative regulation of angiogenesis; negative regulation of myeloid cell apoptosis; triacylglycerol metabolic process; negative regulation of fibrinolysis; positive regulation of blood coagulation; negative regulation of endothelial cell proliferation; positive regulation of lipoprotein lipase activity; negative regulation of blood coagulation; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis