Rabbit NPAS1 Polyclonal Antibody | anti-NPAS1 antibody

NPAS1 Polyclonal Antibody

Cat. Num. AAA3006025

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: NPAS1; Polyclonal Antibody; NPAS1 Polyclonal Antibody; Neuronal PAS domain-containing protein 1; Neuronal PAS1; Basic-helix-loop-helix-PAS protein MOP5; Class E basic helix-loop-helix protein 11; bHLHe11; Member of PAS protein 5; PAS domain-containing protein 5; BHLHE11; MOP5; PASD5; anti-NPAS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NPAS1 polyclonal antibody detects endogenous levels of NPAS1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 590

• Applicable Applications for anti-NPAS1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 486-531 of Human NPAS1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of NPAS1 polyclonal antibody at 1:500 dilutionLane1:HEK293T cell lysateLane2:Raw264. 7 cell lysateLane3:Rat kidney tissue lysate)

Related Product Information for anti-NPAS1 antibody

Members of the bHLH-PAS family are transcription factors that contain a basic helix-loop-helix (bHLH) DNA-recognition motif which is located N-terminal to a PAS domain comprised of two imperfect direct repeats. Human NPAS1 is a deduced 590-amino acid protein which shares 86% sequence homology with mouse Npas1. In order for NPAS1 to bind DNA efficiently, it must form a dimer with another bHLH protein. NPAS1 interacts with ARNT (aryl hydrocarbon receptor nuclear translocator), and shows predominant expression in brain tissue. NPAS1 is also implicated in the control of regulatory pathways relevant to schizophrenia and to psychotic illness, and may play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen levels.

NCBI and Uniprot Product Information

• NCBI GI #: 22027482
• NCBI Accession #: NP_002508.2
• NCBI GenBank Nucleotide #: NP_002508.2
• UniProt Accession #: Q99742
• Molecular Weight: ~ 63kDa
• NCBI Official Full Name: neuronal PAS domain-containing protein 1 isoform 1
• UniProt Protein Name: Neuronal PAS domain-containing protein 1
• Protein Family: Neuronal PAS domain-containing protein
• UniProt Gene Name: NPAS1
• UniProt Synonym Gene Names: BHLHE11; MOP5; PASD5; Neuronal PAS1; bHLHe11
• UniProt Entry Name: NPAS1_HUMAN

Uniprot Description

NPAS1: May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 19q13.2-q13.3

Cellular Component: nucleus

Molecular Function: protein dimerization activity; signal transducer activity; DNA binding; transcription factor activity

Biological Process: startle response; central nervous system development; transcription, DNA-dependent; maternal behavior; negative regulation of transcription from RNA polymerase II promoter; signal transduction