Western Blot (WB)
(ANPEP Antibody western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ANPEP antibody detected the ANPEP protein (arrow).)
Mouse anti-Human ANPEP Monoclonal Antibody | anti-ANPEP antibody
ANPEP Antibody
Western Blot (WB)
(ANPEP Antibody western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ANPEP antibody detected the ANPEP protein (arrow).)
Western Blot (WB)
(ANPEP Antibody western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the ANPEP antibody detected the ANPEP protein (arrow).)
renal microvillar membrane, and also in other plasma membranes. In
the small intestine aminopeptidase N plays a role in the final
digestion of peptides generated from hydrolysis of proteins by
gastric and pancreatic proteases. Its function in proximal tubular
epithelial cells and other cell types is less clear. The large
extracellular carboxyterminal domain contains a pentapeptide
consensus sequence characteristic of members of the zinc-binding
metalloproteinase superfamily. Sequence comparisons with known
enzymes of this class showed that CD13 and aminopeptidase N are
identical. The latter enzyme was thought to be involved in the
metabolism of regulatory peptides by diverse cell types, including
small intestinal and renal tubular epithelial cells, macrophages,
granulocytes, and synaptic membranes from the CNS. Human
aminopeptidase N is a receptor for one strain of human coronavirus
that is an important cause of upper respiratory tract infections.
Defects in this gene appear to be a cause of various types of
leukemia or lymphoma.
Curnis, F., et al. J. Biol. Chem. 285(12):9114-9123(2010)
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
Ito, S., et al. Gen Thorac Cardiovasc Surg 57(11):591-598(2009)
Ju, S., et al. Cell Cycle 8(16):2578-2585(2009)
NCBI and Uniprot Product Information
NCBI Description
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
Uniprot Description
CD13: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types including small intestinal and tubular epithelial cells, macrophages, granulocytes and synaptic membranes from the CNS. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. Belongs to the peptidase M1 family.
Protein type: EC 3.4.11.2; Membrane protein, integral; Receptor, misc.; Other Amino Acids Metabolism - glutathione; Protease
Chromosomal Location of Human Ortholog: 15q25-q26
Cellular Component: extracellular space; integral to plasma membrane; lysosomal membrane; ER-Golgi intermediate compartment; cytosol; external side of plasma membrane
Molecular Function: viral receptor activity; zinc ion binding; metallopeptidase activity; receptor activity; aminopeptidase activity
Biological Process: entry of virus into host cell; cellular protein metabolic process; angiogenesis; proteolysis; cell differentiation; angiotensin maturation
Research Articles on ANPEP
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Product Notes
The ANPEP anpep (Catalog #AAA9200489) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ANPEP Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ANPEP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:100~500. Researchers should empirically determine the suitability of the ANPEP anpep for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ANPEP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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