Mouse anti-Human 26S proteasome non-ATPase regulatory subunit 11 Monoclonal Antibody | anti-PSMD11 antibody

Mouse Anti Human 26S proteasome non-ATPase regulatory subunit 11 clone PAT2C7AT

Cat. Num. AAA146970

• Gene Names: PSMD11; S9; Rpn6; p44.5
• Reactivity: Human
• Applications: ELISA, Western Blot, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence
• Purity: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Synonyms: 26S proteasome non-ATPase regulatory subunit 11; Monoclonal Antibody; Mouse Anti Human 26S proteasome non-ATPase regulatory subunit 11 clone PAT2C7AT; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit p44.5; PSMD11; S9; Rpn6; p44.5; MGC3844; PSMD11 PAT2C7AT Antibody; 26S proteasome non-ATPase regulatory subunit 11 clone PAT2C7AT Mouse Anti Human; anti-PSMD11 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b heavy chain and k light chain
• Clone Number: PAT2C7AT
• Purity/Purification: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Form/Format: Sterile filtered colorless solution; 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide
• Sequence Length: 422

• Applicable Applications for anti-PSMD11 antibody: ELISA (EIA), Western Blot (WB), Flow cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Immunogen: Anti-human PSMD11 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PSMD11 PAT2C7AT amino acids 1-422 purified from E Coli
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at-20 degree C.; Prevent freeze thaw cycles

Related Product Information for anti-PSMD11 antibody

The 26S proteasome is a multicatalytic proteinase complex with a well ordered structure composed of two complexes- a 20S core and a 19S regulator. PSMD11 is a non-ATPase subunit of the 19S regulator. The 20S core is composed of four rings of 28 non-identical subunits; two rings are composed of 7 alpha subunits and two rings are composed of 7 beta subunits. The 19S regulator is composed of a base that contains six ATPase subunits and two non-ATPase subunits, and a lid that contains up to ten non-ATPase subunits. Proteasomes are spread throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An indispensable function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

Product Categories/Family for anti-PSMD11 antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme; PSMD11 PAT2C7AT Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 394953908
• NCBI GeneID: 5717
• NCBI Accession #: NP_001257411.1
• NCBI GenBank Nucleotide #: NM_001270482.1
• UniProt Accession #: O00231; O00495; Q53FT5; A8K3I7; E1P663
• Molecular Weight: 47,535 Da
• NCBI Official Full Name: 26S proteasome non-ATPase regulatory subunit 11
• NCBI Official Synonym Full Names: proteasome 26S subunit, non-ATPase 11
• NCBI Official Symbol: PSMD11
• NCBI Official Synonym Symbols: S9; Rpn6; p44.5
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 11
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 11
• Protein Family: 26S proteasome non-ATPase regulatory
• UniProt Gene Name: PSMD11

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.