Monkey Ras-Specific Guanine Nucleotide-Releasing Factor 2 (RASGRF2) ELISA Kit | RASGRF2 elisa kit
Monkey Ras-Specific Guanine Nucleotide-Releasing Factor 2 (RASGRF2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]
Uniprot Description
RASGRF2: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane
Molecular Function: calmodulin binding; guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: MAPK cascade; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
Research Articles on RASGRF2
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Product Notes
The Monkey RASGRF2 rasgrf2 (Catalog #AAA9900702) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9900702 ELISA Kit recognizes Monkey RASGRF2. It is sometimes possible for the material contained within the vial of "Ras-Specific Guanine Nucleotide-Releasing Factor 2 (RASGRF2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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