Cathepsin B, Human Liver Active Protein | CTSB active protein

Cathepsin B, Human Liver

Cat. Num. AAA135718

• Gene Names: CTSB; APPS; CPSB
• Purity: >95% by SDS-PAGE analysis
• Synonyms: Cathepsin B; Human Liver; CTSB active protein

• Host: Human liver
• Purity/Purification: >95% by SDS-PAGE analysis
• Form/Format: Frozen liquid
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 339

• Specific Activity: 439 units/mg (One unit will hydrolyze one micromole of Z-Arg-Arg-beta-naphthylamide per minute at 40 C, pH 6.0, in the presence of DTT)
• Buffer: 0.05M Sodium Acetate; 1mM EDTA; pH 5.0
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this produ
• Preparation and Storage: Store at -70 degree C.

Testing Data

Related Product Information for CTSB active protein

Cathepsin B, a cysteine proteinase, is located in lysosomes and is involved in tissue degradation and restructuring. Specifically, cathepsin B is believed to be involved in the intracellular digestion of extracellular proteins taken up by endocytosis. Act

Product Categories/Family for CTSB active protein

Cathepsin; Human Cathepsins

NCBI and Uniprot Product Information

• NCBI GI #: 4503139
• NCBI GeneID: 1508
• NCBI Accession #: NP_001899.1
• NCBI GenBank Nucleotide #: NM_001908.3
• UniProt Accession #: P07858; Q503A6; Q96D87; B3KQR5; B3KRR5
• Molecular Weight: 27,500
• NCBI Official Full Name: cathepsin B preproprotein
• NCBI Official Synonym Full Names: cathepsin B
• NCBI Official Symbol: CTSB
• NCBI Official Synonym Symbols: APPS; CPSB
• NCBI Protein Information: cathepsin B; cathepsin B1; APP secretase; cysteine protease; amyloid precursor protein secretase
• UniProt Protein Name: Cathepsin B
• Protein Family: Cathepsin
• UniProt Gene Name: CTSB
• UniProt Synonym Gene Names: CPSB; APPS
• UniProt Entry Name: CATB_HUMAN

NCBI Description

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.1; Motility/polarity/chemotaxis; Protease; Autophagy

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular space; intracellular membrane-bound organelle; mitochondrion; perinuclear region of cytoplasm; lysosome; nucleolus; melanosome; extracellular region; intracellular

Molecular Function: collagen binding; peptidase activity; proteoglycan binding; protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: regulation of apoptosis; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; epithelial cell differentiation; proteolysis involved in cellular protein catabolic process; regulation of catalytic activity; toll-like receptor signaling pathway; innate immune response; decidualization; proteolysis