NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Uniprot Description
LYPLA1: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. Belongs to the AB hydrolase 2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Phospholipase; Lipid Metabolism - glycerophospholipid; EC 3.1.2.-
Chromosomal Location of Human Ortholog: 8q11.23
Cellular Component: mitochondrion; cytosol
Molecular Function: palmitoyl-(protein) hydrolase activity; lysophospholipase activity
Biological Process: negative regulation of Golgi to plasma membrane protein transport; regulation of nitric-oxide synthase activity; fatty acid metabolic process; nitric oxide metabolic process; protein depalmitoylation
Research Articles on GHRELIN
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Product Notes
The Monkey GHRELIN lypla1 (Catalog #AAA028159) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA028159 ELISA Kit recognizes Monkey GHRELIN. It is sometimes possible for the material contained within the vial of "Acyl Ghrelin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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