FPS-ZM1 modulator
FPS-ZM1
Purity
>98%
Synonyms
FPS-ZM1; FPS-ZM1 modulator
Purity/Purification
>98%
Form/Format
Powder
Bio-Activity
RAGE antagonist; Neuroprotectant
Solubility
Soluble in DMSO (up to 30mg/ml) or in Ethanol (up to 25mg/ml)
Chemical Name
4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
CAS #
945714-67-0
Molecular Formula
C20H22ClNO
Preparation and Storage
Store at -20 degree C
Related Product Information for FPS-ZM1 modulator
FPS-ZM1 is a receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6uM). It decreases the amount of Abeta by binding to the V domain of RAGE. It also blocks multiple mechanisms of Abeta40- and Abeta42-induced cellular stress in RAGE-expressing brain endothelium, neurons, and microglia in vitro and in vivo (1,2). FPS-ZM1 has also shown the ability to cross the BBB. In a rat model, it was able to cross the blood-brain barrier and cause white matter fiber damage (3). FPS-ZM1 inhibition of RAGE was able to ameliorate inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling (4). Lastly, it also plays a role in breast cancer cell invasion and metastasis, impairing it (5).
Product Categories/Family for FPS-ZM1 modulator
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Product Notes
The FPS-ZM1 (Catalog #AAA556523) is a Modulator and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FPS-ZM1, Modulator" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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