MLYCD / Malonyl-CoA Decarboxylase Recombinant Protein | MLYCD recombinant protein

Human MLYCD / Malonyl-CoA Decarboxylase, Mitochondrial Recombinant Protein

• Gene Names: MLYCD; MCD
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: MLYCD / Malonyl-CoA Decarboxylase; Human MLYCD / Malonyl-CoA Decarboxylase; Mitochondrial Recombinant Protein; Malonyl-CoA decarboxylase; mitochondrial; MCD; MLYCD recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 493

• Applicable Applications for MLYCD recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide-linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5.
• Entry Function: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 110349750
• NCBI GeneID: 23417
• NCBI Accession #: NP_036345
• NCBI GenBank Nucleotide #: NP_036345.2
• UniProt Accession #: O95822
• NCBI Official Full Name: malonyl-CoA decarboxylase, mitochondrial
• NCBI Official Synonym Full Names: malonyl-CoA decarboxylase
• NCBI Official Symbol: MLYCD
• NCBI Official Synonym Symbols: MCD
• NCBI Protein Information: malonyl-CoA decarboxylase, mitochondrial
• UniProt Protein Name: Malonyl-CoA decarboxylase, mitochondrial
• Protein Family: Malonyl-CoA decarboxylase
• UniProt Gene Name: MLYCD
• UniProt Synonym Gene Names: MCD
• UniProt Entry Name: DCMC_HUMAN

NCBI Description

The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]